From: Oncological outcomes in an Australian cohort according to the new prostate cancer grading groupings
Treatment sub-group | No. Events/Total | Competing risk regression | |||
---|---|---|---|---|---|
Unadjusted sHR (95%CI) | p-value | Adjusted sHRa (95%CI) | p-value | ||
All men | 259/4264 | ||||
Grade group I (3 + 3) | 40/1780 | 1.0 | - | 1.00 | |
Grade group II (3 + 4) | 52/1154 | 2.1 (1.4–3.2) | <0.001 | 2.2 (1.5–3.6) | <0.001 |
Grade group III (4 + 3) | 42/645 | 3.2 (2.1–4.9) | <0.001 | 2.5 (1.6–4.2) | <0.001 |
Grade group IV (8) | 48/399 | 6.1 (4.0–9.2) | <0.001 | 4.1 (2.6–6.7) | <0.001 |
Grade group V (9–10) | 77/286 | 16.8 (11.4–24.7) | <0.001 | 8.7 (5.4–14.0) | <0.001 |
P for trend | <0.001 | <0.001 | |||
Conservative managementb | 136/1033 | ||||
Grade group I (3 + 3) | 19/518 | 1.0 | - | 1.00 | |
Grade group II (3 + 4) | 25/163 | 4.3 (2.4–7.8) | <0.001 | 3.0 (1.5–5.8) | 0.001 |
Grade group III (4 + 3) | 17/122 | 3.9 (2.1–7.4) | <0.001 | 2.2 (1.0–4.8) | 0.04 |
Grade group IV (8) | 26/110 | 6.9 (3.8–12.4) | <0.001 | 4.1 (2.0–8.4) | <0.001 |
Grade group V (9–10) | 49/120 | 15.2 (8.9–25.8) | <0.001 | 8.5 (4.2–17.2) | <0.001 |
P for trend | <0.001 | <0.001 | |||
Radical prostatectomy | 22/1624 | ||||
Grade group I (3 + 3) | 4/637 | 1.0 | - | 1.0 | - |
Grade group II (3 + 4) | 5/568 | 1.7 (0.5–6.2) | 0.44 | 1.6 (0.4–6.1) | 0.48 |
Grade group III (4 + 3) | 3/254 | 2.4 (0.5–10.5) | 0.26 | 2.3 (0.5–10.9) | 0.29 |
Grade group IV (8) | 6/126 | 9.5 (2.6–33.8) | 0.001 | 9.5 (2.6–35.8) | 0.001 |
Grade group V (9–10) | 4/39 | 29.1 (7.1–120) | <0.001 | 28.4 (6.4–124) | <0.001 |
P for trend | <0.001 | <0.001 | |||
Curative radiotherapy | 75/1143 | ||||
Grade group I (3 + 3) | 15/385 | 1.0 | - | 1.00 | - |
Grade group II (3 + 4) | 19/314 | 1.8 (0.9–3.5) | 0.10 | 1.4 (0.7–3.0) | 0.37 |
Grade group III (4 + 3) | 19/218 | 2.7 (1.4–5.5) | 0.003 | 2.3 (1.1–4.8) | 0.03 |
Grade group IV (8) | 10/125 | 2.6 (1.2–5.8) | 0.02 | 2.0 (0.8–7.8) | 0.13 |
Grade group V (9–10) | 12/101 | 4.2 (2.0–9.0) | <0.001 | 2.8 (1.2–6.8) | 0.02 |
P for trend | <0.001 | <0.001 |