Angiopoietin-1 deficiency increases tumor metastasis in mice

BMC Cancer

Table 1 RNA-seq of mammary tumors

Gene	Sign. Change	FVB	PyMT
Angpt1		270	210
Angpt2	↓	146	30
Angpt4		0	0
Angptl1/Angpt3	↓	46	6.3
Angptl2	↓	2430	308
Angptl3		6.0	0
Angptl4	↓	2138	341
Angptl6		12	9.3
Angptl7		0	1.3
Tek/Tie2	↓	604	96
Tie1	↓	416	105
Vegfa	↓	1621	574
Kdr/Vegfr2	↓	1483	230
Flt/Vegfr1	↓	1243	202
Cxcl12	↓	2241	363
Cxcr2		1	2
Cxcr3		19	2
Cxcr4		145	290

An extract of data from a published data set with RNA sequencing performed on mammary glands from FVB (control) and FVB mice with PyMT mammary tumors with late stage carcinoma [25]. Data are expressed as the average FPKM (n = 4/group) and significant differences are indicated with arrows up (↑) or down (↓) compared to WT

ISSN: 1471-2407