Fig. 2

Angpt1 deficiency increases lung metastasis of B16F10 melanoma experimental metastasis model. a Mean ± SEM for B16F10 subcutaneous tumor volume over 15 days comparing WT (n = 4) and Angpt1 ^Δ/Δ (n = 7) mice. b, c Quantification of lung metastasis of B16F10 melanoma cells 3 weeks after tail vein injection in Angpt1 ^Δ/Δ mice (n = 20) compared to WT mice (n = 19). d Quantification of lung metastasis of B16F10 melanoma cells 3 weeks after tail vein injection in Tek ^Δ/Δ mice (n = 14) compared to WT mice (n = 15). Data is shown as mean ± 95% CI. ***p < 0.001. e, f Size of lung metastatic foci in WT and Angpt1 ^Δ/Δ MMTV-PyMT mice (e) and B16F10 experimental metastasis model (f). Data is shown as mean ± 95% CI