Fig. 1
From: Angiopoietin-1 deficiency increases tumor metastasis in mice
Angpt1 deficiency increases lung metastasis in MMTV-PyMT mammary tumor model. a Bodyweight ± SEM from 6 weeks until 16 weeks of age for female MMTV-PyMT-Angpt1 Δ/Δ (n = 4), MMTV-PyMT-WT (n = 5), Angpt1 Δ/Δ (n = 7) and WT (n = 10) mice. b Mean ± 95% CI for mammary tumor volumes was similar in MMTV-PyMT- Angpt1 Δ/Δ and MMTV-PyMT-WT mice at 16 weeks. c Mean ± 95% CI for metastasis/lung area show a significant increase in metastasis in MMTV-PyMT-Angpt1 Δ/Δ compared to MMTV-PyMT-WT mice. **p < 0.01. d Lungs with tumors stained for MMTV-PyMT