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Table 3 Primary tumor characteristics of the cohorts according to genotype

From: Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care

 

BRAF n = 87 (100.0)

NRAS n = 53 (100.0)

Wild type n = 72 (100.0)

Total n = 212a (100.0)

p-value

Localization

 Acral

3 (3.5)

4 (8.0)

14 (19.4)

21 (10.1)

0.002*

 Head / neck

14 (16.5)

5 (10.0)

15 (20.8)

34 (16.4)

 Arms

7 (8.2)

10 (20.0)

10 (13.9)

27 (13.0)

 Trunk

39 (45.9)

19 (38.0)

15 (20.8)

73 (35.3)

 Legs

22 (25.9)

10 (20.0)

14 (19.4)

46 (22.2)

 Mucosal

0 (0.0)

2 (4.0)

4 (5.6)

6 (2.9)

Histologic subtypea

 ALM

3 (3.53)

2 (4.0)

11 (15.3)

16 (7.7)

0.021

 LMM

2 (2.35)

0 (0.0)

2 (2.78)

4 (1.93)

 NM

32 (37.7)

26 (52.0)

27 (37.5)

85 (41.1)

 SSM

37 (43.5)

14 (28.0)

17 (23.6)

68 (32.9)

 unclassified

11 (12.9)

8 (16.0)

15 (20.8)

34 (16.4)

Breslow’s indexb

 ≤ 1.00 mm

43 (50.6)

26 (52.0)

32 (45.1)

101 (49.0)

0.241

 1.01 – 2.00 mm

21 (24.7)

9 (18.0)

14 (19.7)

44 (21.3)

 2.01 – 4.00 mm

17 (20.0)

8 (16.0)

12 (16.9)

37 (18.0)

 ≥ 4.01 mm

4 (4.7)

7 (14.0)

13 (18.3)

24 (11.7)

Clark levelc

 II

3 (3.8)

1 (2.3)

4 (6.6)

8 (4.4)

0.094

 III

25 (31.3)

9 (20.9)

9 (14.8)

43 (23.4)

 IV

45 (56.3)

30 (69.8)

36 (59.0)

111 (60.3)

 V

7 (8.8)

3 (7.0)

12 (19.7)

22 (12.0)

Ulzerationd

 no

49 (60.5)

23 (47.9)

36 (50.7)

108 (54.0)

0.301

 yes

32 (39.5)

25 (52.1)

35 (49.3)

92 (46.0)

Mitotic activitye

 no

15 (37.5)

4 (16.0)

3 (7.0)

22 (20.4)

0.002*

 yes

25 (62.5)

21 (84.0)

40 (93.0)

86 (79.6)

  1. Pathologic features of the primary tumors are indicated according to genotype. The categorical variables were compared with the Chi-square test; the significance level was adjusted with the Bonferroni correction with p < 0.008 considered significant (*). Mitotic activity was defined as presence of ≥ 1 mitosis per high power field. aNo data on the histologic subtype for n = 5; bno data on Breslow’s index for n = 6; cno data on Clark level available for n = 28; dulceration unknown for n = 12; emissing data for mitotic activity in primary tumors for n = 104; ALM acral lentiginous melanoma, LMM lentigo maligna melanoma, NM nodular melanoma, SSM superficial spreading melanoma