Fig. 1

Time from primary diagnosis to first disease progression of any type (a), first loco-regional relapse (b), and first detection of distant metastases (c). Times to the respective events were calculated with the cumulative incidence function and are indicated in years. The BRAF mutant cohort showed the longest time to progression with the median time to first nodal relapse not being reached in the observation period (b). In contrast, the NRAS mutant cohort had the shortest time to nodal relapse (b), while the median time to progression of any type (a) or to the formation of distant metastases (c) was almost equal in NRAS mutant and WT melanoma patients. Patients who initially presented with stage IV disease (n = 8) were precluded from the analyses shown in (b) and (c). The right panels of (b) and (c) indicate progression curves after selection for patients with relapse. The indicated p-values were calculated with the Gray’s test