Dose level 1 | Dose level 2 | All N = 25 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Nephrec-tomized N = 4 | Non nephrec-tomized N = 11 | All N = 15 | Nephrec-tomized N = 3 | Non nephrec-tomized N = 7 | All N = 10 | |||||
N | N | N | % | N | N | N | % | N | % | |
Thrombotic microangiopathy (TMA) | 0 | 2 | 2 | 13.3 | 1 | 1 | 2 | 20.0 | 4 | 16.0 |
Thrombocytopenia | 0 | 2 | 2 | 13.3 | 0 | 1 | 1 | 10.0 | 3 | 12.0 |
Elevated ALT and/or AST | 0 | 1 | 1 | 6.7 | 1 | 1 | 2 | 20.0 | 3 | 12.0 |
Abdominal pain | 0 | 1 | 1 | 6.7 | 0 | 1 | 1 | 10.0 | 2 | 8.0 |
Thoracic musculoskeletal pain | 0 | 2 | 2 | 13.3 | 0 | 0 | 0 | 0.0 | 2 | 8.0 |
Hypertension | 0 | 0 | 0 | 0.0 | 1 | 1 | 2 | 20.0 | 2 | 8.0 |
Proteinuria | 1 | 0 | 1 | 6.7 | 0 | 1 | 1 | 10.0 | 2 | 8.0 |
Perianal abscess | 1 | 0 | 1 | 6.7 | 0 | 0 | 0 | 0.0 | 1 | 4.0 |
Seizure | 0 | 1 | 1 | 6.7 | 0 | 0 | 0 | 0.0 | 1 | 4.0 |
Diarrhea | 0 | 0 | 0 | 0.0 | 0 | 1 | 1 | 10.0 | 1 | 4.0 |
Confusiona | 0 | 1 | 1 | 6.7 | 0 | 0 | 0 | 0.0 | 1 | 4.0 |
Fatigue | 0 | 1 | 1 | 6.7 | 0 | 0 | 0 | 0.0 | 1 | 4.0 |
Hypernatremia | 0 | 0 | 0 | 0.0 | 1 | 0 | 1 | 10.0 | 1 | 4.0 |
Post-surgery bleeding | 0 | 0 | 0 | 0.0 | 1 | 0 | 1 | 10.0 | 1 | 4.0 |
Lipase increase | 0 | 0 | 0 | 0.0 | 1 | 0 | 1 | 10.0 | 1 | 4.0 |
Pyelonephritis | 0 | 1 | 1 | 6.7 | 0 | 0 | 0 | 0.0 | 1 | 4.0 |
Hand & foot syndrome | 1 | 0 | 1 | 6.7 | 0 | 0 | 0 | 0.0 | 1 | 4.0 |
Venous thrombosis | 0 | 0 | 0 | 0.0 | 1 | 0 | 1 | 10.0 | 1 | 4.0 |
Vomiting | 0 | 1 | 1 | 6.7 | 0 | 0 | 0 | 0.0 | 1 | 4.0 |