Table 2 Predicted upstream regulators in GOT1 tumors after sonidegib, 177Lu-octreotate, or a combination of both treatments
Upstream Regulator | Molecule Type | Â | p-value: | Â | Targets from data |
|---|---|---|---|---|---|
Sonidegib | 177Lu-octreotate | Combination | |||
A | |||||
SUZ12 | Enzyme | 2.0·10−2 | 4.6·10−3 | 1.3·10−4 | UP: CDKN2A, HSD17B11, LITAF DOWN: CXCR7, KCNA1, RBMS1 |
CTBP1 | Enzyme | 2.4·10−3 | 3.9·10−2 | 1.3·10−2 | UP: CDKN1A DOWN: CXCR7 |
PRKCA | Kinase | 1.2·10−2 | 1.9·10−2 | 2.5·10−3 | DOWN: BCL11A, EGR1, ETS1, HSPA1B, PVR |
HIC1 | Transcription regulator | 1.6·10−2 | 2.9·10−2 | 3.3·10−2 | UP: CDO1 DOWN: CXCR7, ID4, KCNJ6 |
miR-292b-5p | Mature microRNA | 1.1·10−3 | 1.8·10−2 | - | DOWN: BCL11A |
LIN28B | Other | 1.3·10−3 | 2.2·10−2 | - | DOWN: BCL11A |
CHD4 | Enzyme | 2.7·10−3 | 4.4·10−2 | - | DOWN: BCL11A |
EZH2 | Transcription regulator | 2.4·10−2 | 8.1·10−3 | - | DOWN: CXCR7, KCNA1, NFKBIA |
MAPK1 | Kinase | 4.2·10−2 | 3.5·10−2 | - | UP: HBA2 DOWN: BCL11A, CTNNA2 |
Histone h3 | Group | 3.9·10−2 | - | 2.1·10−4 | UP: BTG3, CDKN1A, CDKN2A, ENO3, PCNA, RGS10, STOM DOWN: CXCR7, NFKBIA, SOD2 |
Ctbp | Group | 3.2·10−3 | - | 2.3·10−2 | UP: CDKN2A DOWN: CXCR7 |
ETS1 | Transcription regulator | 1.7·10−2 | - | 4.2·10−2 | DOWN: BCL11A, CTGF, HSPA1B, PVR |
B | |||||
Upstream Regulator | Molecule Type | z | p-value | Targets from data | |
INS | Other | −2.1 | 2.6·10−4 | UP: CBS, LPL DOWN: EGR1, OGT, SREBF1 | |
FSH | Complex | 2.2 | 7.5·10−3 | UP: DLX5, GNAS, PMAIP1, RGS16, SC4MOL DOWN: BCL11A, DUSP3, FILIP1L, FLNC, ILK, ITGA3, TPM2 | |
Lh | Complex | 2.2 | 2.4·10−2 | UP: GNAS, PMAIP1, RGS16, SC4MOL DOWN: DUSP3, FLNC, ILK, ITGA3, TPM2 | |