Fig. 4

Expression of proteins in the Hh- and PI3K/AKT/mTOR pathways in GOT1 tumors after sonidegib, ¹⁷⁷Lu-octreotate and combination treatment. Expression of Hh-related (GLI1, GLI2) and PI3K/AKT/mTOR-related (AKT, p-AKT, S6) proteins in tumors treated with sonidegib, ¹⁷⁷Lu-octreotate, or a combination of both pharmaceutical agents, and untreated controls, measured using western blot analysis. Representative immunoblots from each group are shown. + and - indicates treated and untreated, respectively