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Fig. 3 | BMC Cancer

Fig. 3

From: Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice

Fig. 3

Expression of genes associated to cell death and/or cell cycle regulation in GOT1 tumors after 177Lu-octreotate and combination treatment. Differential expression (treated vs. control) of transcripts associated with cell death- and/or cell cycle regulation-processes in tumor samples from animals treated with 177Lu-octreotate (black), or a combination of sonidegib and 177Lu-octreotate (gray). No significant association with cell death or cell cycle regulation was found in tumor samples from animals treated with sonidegib monotherapy. Transcripts with |log2(fold change)| ≥ 0.58 and adjusted p < 0.01 were considered significantly regulated, association to biological processes was performed using the Gene Ontology database (threshold p < 0.05). Up- and downregulation is indicated by positive and negative values, respectively

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