Fig. 1

Anti-tumor effects of sonidegib, ¹⁷⁷Lu-octreotate and combination treatment on GOT1 tumors in nude mice. a mean relative tumor volume versus time for controls and animals treated with sonidegib, ¹⁷⁷Lu-octreotate, or a combination of both. b mean tumor volume versus time, until the first animal had to be killed on account of too high tumor burden, in each treatment group and controls. c percentage of animals in each treatment group without tumor progression. Error bars indicate SD. x, †, ‡ and * indicate time points with statistically significant differences between sonidegib and control, ¹⁷⁷Lu-octreotate and control, combination and control, and combination and sonidegib treatment groups, respectively (Student’s t-test, p < 0.05). ↓ indicates the time for treatment start