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Table 2 Univariate and multivariate cox hazards analysis for overall survival in 447 patients with ESCC

From: Prognostic value of pretreatment serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in patients with esophageal squamous cell carcinoma

  Univariate analysis Multivariate analysis
Variables HR 95% CI p value** HR 95% CI p value**
Gender
 Male vs. Female 1.119 0.837–1.497 0.448 0.876 0.679–1.131 0.310
Age (years)
  < 59 vs. ≥ 59 0.985 0.768–1.264 0.905 1.124 0.838–1.506 0.435
Histological differentiation (129)
 Differentiated vs. Undifferentiated 1.242 0.908–1.701 0.176    
T classification
 T3–4 vs. T1–2 1.851 1.356–2.525 0.000    
N classification
 Yes vs. No 3.029 2.324–3.948 0.000    
Metastasis
 Yes vs. No 4.049 2.308–7.103 0.000    
TNM stage
 III-IV vs. I-II 3.132 2.048–4.074 0.000 2.956 2.269–3.852 0.000
Tumor location
 Upper vs. Middle vs. Lower 1.215 0.984–1.501 0.071    
Alcohol history
 Yes vs. No 1.346 1.049–1.728 0.020 1.238 0.950–1.612 0.114
Treatment(n)
 Surgery only 1.235 1.063–1.434 0.006 1.083 0.953–1.231 0.221
Surgery and chemotherapy
Surgery and radiotherapy
Surgery and chemotherapy and radiotherapy
Tests
GGT
  ≥ 23.1 vs. <23.1 1.395 1.085–1.793 0.01 1.507 1.163–1.953 0.002
LDH
  ≥ 154.4 vs. <154.4 1.046 0.815–1.344 0.722    
TBA
  ≥ 4.14 vs. < 4.14 1.172 0.912–1.506 0.215    
ALT
  ≥ 15.1 vs. < 15.1 0.718 0.558–0.924 0.01 0.913 0.658–1.268 0.588
AST
  ≥ 18.2 vs. <18.2 1.021 0.795–1.312 0.87    
ALT/AST(LSR)
  ≥ 0.82 vs. <0.82 0.615 0.478–0.792 0.000 0.592 0.457–0.768 0.000
  1. HR Hazard ratio, 95% CI 95% confidence interval
  2. **Cox hazard regression model