Table 2 Univariate and multivariate cox hazards analysis for overall survival in 447 patients with ESCC
| Â | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Variables | HR | 95% CI | p value** | HR | 95% CI | p value** |
Gender | ||||||
 Male vs. Female | 1.119 | 0.837–1.497 | 0.448 | 0.876 | 0.679–1.131 | 0.310 |
Age (years) | ||||||
  < 59 vs. ≥ 59 | 0.985 | 0.768–1.264 | 0.905 | 1.124 | 0.838–1.506 | 0.435 |
Histological differentiation (129) | ||||||
 Differentiated vs. Undifferentiated | 1.242 | 0.908–1.701 | 0.176 |  |  |  |
T classification | ||||||
 T3–4 vs. T1–2 | 1.851 | 1.356–2.525 | 0.000 |  |  |  |
N classification | ||||||
 Yes vs. No | 3.029 | 2.324–3.948 | 0.000 |  |  |  |
Metastasis | ||||||
 Yes vs. No | 4.049 | 2.308–7.103 | 0.000 |  |  |  |
TNM stage | ||||||
 III-IV vs. I-II | 3.132 | 2.048–4.074 | 0.000 | 2.956 | 2.269–3.852 | 0.000 |
Tumor location | ||||||
 Upper vs. Middle vs. Lower | 1.215 | 0.984–1.501 | 0.071 |  |  |  |
Alcohol history | ||||||
 Yes vs. No | 1.346 | 1.049–1.728 | 0.020 | 1.238 | 0.950–1.612 | 0.114 |
Treatment(n) | ||||||
 Surgery only | 1.235 | 1.063–1.434 | 0.006 | 1.083 | 0.953–1.231 | 0.221 |
Surgery and chemotherapy | ||||||
Surgery and radiotherapy | ||||||
Surgery and chemotherapy and radiotherapy | ||||||
Tests | ||||||
GGT | ||||||
  ≥ 23.1 vs. <23.1 | 1.395 | 1.085–1.793 | 0.01 | 1.507 | 1.163–1.953 | 0.002 |
LDH | ||||||
  ≥ 154.4 vs. <154.4 | 1.046 | 0.815–1.344 | 0.722 |  |  |  |
TBA | ||||||
  ≥ 4.14 vs. < 4.14 | 1.172 | 0.912–1.506 | 0.215 |  |  |  |
ALT | ||||||
  ≥ 15.1 vs. < 15.1 | 0.718 | 0.558–0.924 | 0.01 | 0.913 | 0.658–1.268 | 0.588 |
AST | ||||||
  ≥ 18.2 vs. <18.2 | 1.021 | 0.795–1.312 | 0.87 |  |  |  |
ALT/AST(LSR) | ||||||
  ≥ 0.82 vs. <0.82 | 0.615 | 0.478–0.792 | 0.000 | 0.592 | 0.457–0.768 | 0.000 |