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Fig. 1 | BMC Cancer

Fig. 1

From: The clonal evolution of two distinct T315I-positive BCR-ABL1 subclones in a Philadelphia-positive acute lymphoblastic leukemia failing multiple lines of therapy: a case report

Fig. 1

Example of clonal analysis for sample ALL-8. a) Conventional Sanger Sequencing results showing the double nucleotide substitution at codon 315; b) screenshot showing a portion of the global alignment of sequence reads obtained with AVA software, where codon 315 maps. Deep Sequencing allowed to resolve two distinct populations of mutants at this codon, one harboring the T315I (att) and one harboring the T315I (atc). Sequence were compared to the wild-type sequence (green at the top) using BLAST, GenBank Accession Number X16416

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