Table 6 Univariate and multivariate analysis of predictors of complete response following neoadjuvant chemotherapy in patients with locally advanced cervical cancer who underwent neoadjuvant chemotherapy and radical hysterectomy

Age (years)

1.01

0.99–1.04

0.286

Body mass index (kg/m²)

1.19

1.01–1.39

0.037

1.27

1.04–1.55

0.020

Serum creatinine (μmol/l)

0.97

0.95–0.99

0.001

0.99

0.97–1.02

0.573

Tumor stage (IIA2 vs. IB2)

1.60

1.12–2.30

0.010

0.99

0.73–1.35

0.956

Histology (non-squamous vs. squamous)

1.55

0.64–3.71

0.329

Tumor differentiation (G3 vs. G1–2)

0.91

0.45–1.84

0.784

 No

Reference

Reference

Reference

Reference

Reference

Reference

 HbA_1c < 7%

0.05

0.02–0.14

<0.0001

0.06

0.02–0.17

<0.0001

 HbA_1c ≥ 7%

0.04

0.02–0.10

<0.0001

0.04

0.02–0.11

<0.0001

 Hypertension (yes vs. no)

0.34

0.20–0.59

<0.0001

0.38

0.20–0.74

0.004

 Cardiovascular disease (yes vs. no)

0.84

0.35–2.04

0.700

 Metformin (yes vs. no)

0.64

0.34–1.22

0.174