Table 5 Multivariate Cox analysis of prognostic factors associated with survival for diabetic patients with locally advanced cervical cancer who underwent neoadjuvant chemotherapy and radical hysterectomy
| Â | Recurrence-free survival | Cancer-specific survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value |
Age (years) | |||||||||
Body mass index (kg/m2) | 1.16 | 0.94–1.44 | 0.171 | 1.12 | 0.90–1.38 | 0.312 |  |  |  |
Serum creatinine (μmol/l) | |||||||||
Tumor stage (IIA2 vs. IB2) | 1.64 | 0.78–3.48 | 0.195 | 1.55 | 0.71–3.37 | 0.267 |  |  |  |
Histology (non-squamous vs. squamous) | |||||||||
Tumor differentiation (G3 vs. G1–2) | |||||||||
Deep stromal invasion (yes vs. no) |  |  |  |  |  |  | 1.16 | 0.54–2.52 | 0.702 |
LVSI (yes vs. no) | |||||||||
 Positive margins (yes vs. no) | 2.25 | 0.94–5.39 | 0.070 | 3.21 | 1.31–7.90 | 0.011 | 2.16 | 1.00–4.68 | 0.050 |
 Positive nodes (yes vs. no) | 3.64 | 1.49–8.85 | 0.004 | 3.44 | 1.42–8.35 | 0.006 | 2.73 | 1.37–5.45 | 0.004 |
 Positive parametrium (yes vs. no) | 3.50 | 1.31–9.32 | 0.012 | 2.71 | 1.00–7.35 | 0.049 | 2.16 | 0.88–5.30 | 0.093 |
 Diabetic status (HbA1c ≥ 7% vs. HbA1c < 7%) | 2.18 | 1.02–4.63 | 0.044 | 2.00 | 0.89–4.49 | 0.092 | 2.29 | 1.20–4.35 | 0.012 |
Hypertension (yes vs. no) | |||||||||
Cardiovascular disease (yes vs. no) | |||||||||
Metformin (yes vs. no) | |||||||||
 Complete response (yes vs. no) | 0.82 | 0.39–1.72 | 0.599 | 0.64 | 0.30–1.36 | 0.247 |  |  |  |