| Univariate analysis | Univariate analysis | Univariate analysis | ||||||
---|---|---|---|---|---|---|---|---|---|
 | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value |
Age (years) | 1.00 | 0.96–1.04 | 0.875 | 1.01 | 0.97–1.05 | 0.681 | 0.99 | 0.96–1.03 | 0.698 |
Body mass index (kg/m2) | 1.17 | 0.99–1.39 | 0.065 | 1.18 | 1.00–1.39 | 0.055 | 1.08 | 0.92–1.26 | 0.361 |
Serum creatinine (μmol/l) | 1.00 | 0.98–1.02 | 0.872 | 1.02 | 0.99–1.04 | 0.211 | 1.01 | 0.98–1.03 | 0.610 |
Tumor stage (IIA2 vs. IB2) | 2.04 | 1.07–3.90 | 0.031 | 1.85 | 0.96–3.57 | 0.065 | 1.44 | 0.82–2.54 | 0.207 |
Histology (non-squamous vs. squamous) | 1.31 | 0.62–2.77 | 0.485 | 1.27 | 0.58–2.80 | 0.549 | 1.40 | 0.71–2.76 | 0.332 |
Tumor differentiation (G3 vs. G1–2) | 0.79 | 0.19–3.30 | 0.751 | 0.90 | 0.22–3.76 | 0.888 | 1.07 | 0.33–3.44 | 0.913 |
Deep stromal invasion (yes vs. no) | 1.49 | 0.62–3.58 | 0.371 | 1.55 | 0.68–3.55 | 0.300 | 1.79 | 0.86–3.70 | 0.119 |
LVSI (yes vs. no) | 1.16 | 0.61–2.24 | 0.647 | 1.26 | 0.65–2.44 | 0.503 | 0.96 | 0.54–1.70 | 0.890 |
Positive margins (yes vs. no) | 3.69 | 1.71–7.97 | 0.001 | 4.14 | 1.88–9.13 | <0.0001 | 3.04 | 1.42–6.47 | 0.004 |
Positive nodes (yes vs. no) | 4.81 | 2.19–10.56 | <0.0001 | 4.12 | 1.87–9.07 | <0.0001 | 3.07 | 1.63–5.78 | <0.0001 |
Positive parametrium (yes vs. no) | 5.55 | 2.27–13.55 | <0.0001 | 4.76 | 1.95–11.59 | 0.001 | 3.71 | 1.55–8.89 | 0.003 |
Diabetic status (HbA1c ≥ 7% vs. HbA1c < 7%) | 2.24 | 1.08–4.63 | 0.030 | 2.45 | 1.15–5.22 | 0.020 | 2.17 | 1.15–4.11 | 0.017 |
Hypertension (yes vs. no) | 0.90 | 0.46–1.77 | 0.763 | 0.94 | 0.47–1.86 | 0.854 | 0.90 | 0.50–1.62 | 0.723 |
Cardiovascular disease (yes vs. no) | 0.61 | 0.22–1.73 | 0.355 | 0.51 | 0.18–1.46 | 0.211 | 0.68 | 0.30–1.52 | 0.343 |
Metformin (yes vs. no) | 0.77 | 0.34–1.75 | 0.531 | 0.79 | 0.33–1.90 | 0.595 | 1.22 | 0.62–2.40 | 0.563 |
Complete response (yes vs. no) | 0.56 | 0.29–1.07 | 0.077 | 0.49 | 0.25–0.94 | 0.033 | 0.74 | 0.41–1.33 | 0.316 |