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Table 4 Univariate Cox analysis of prognostic factors associated with survival for diabetic patients with locally advanced cervical cancer who underwent neoadjuvant chemotherapy and radical hysterectomy

From: Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

 

Univariate analysis

Univariate analysis

Univariate analysis

 

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Age (years)

1.00

0.96–1.04

0.875

1.01

0.97–1.05

0.681

0.99

0.96–1.03

0.698

Body mass index (kg/m2)

1.17

0.99–1.39

0.065

1.18

1.00–1.39

0.055

1.08

0.92–1.26

0.361

Serum creatinine (μmol/l)

1.00

0.98–1.02

0.872

1.02

0.99–1.04

0.211

1.01

0.98–1.03

0.610

Tumor stage (IIA2 vs. IB2)

2.04

1.07–3.90

0.031

1.85

0.96–3.57

0.065

1.44

0.82–2.54

0.207

Histology (non-squamous vs. squamous)

1.31

0.62–2.77

0.485

1.27

0.58–2.80

0.549

1.40

0.71–2.76

0.332

Tumor differentiation (G3 vs. G1–2)

0.79

0.19–3.30

0.751

0.90

0.22–3.76

0.888

1.07

0.33–3.44

0.913

Deep stromal invasion (yes vs. no)

1.49

0.62–3.58

0.371

1.55

0.68–3.55

0.300

1.79

0.86–3.70

0.119

LVSI (yes vs. no)

1.16

0.61–2.24

0.647

1.26

0.65–2.44

0.503

0.96

0.54–1.70

0.890

Positive margins (yes vs. no)

3.69

1.71–7.97

0.001

4.14

1.88–9.13

<0.0001

3.04

1.42–6.47

0.004

Positive nodes (yes vs. no)

4.81

2.19–10.56

<0.0001

4.12

1.87–9.07

<0.0001

3.07

1.63–5.78

<0.0001

Positive parametrium (yes vs. no)

5.55

2.27–13.55

<0.0001

4.76

1.95–11.59

0.001

3.71

1.55–8.89

0.003

Diabetic status (HbA1c ≥ 7% vs. HbA1c < 7%)

2.24

1.08–4.63

0.030

2.45

1.15–5.22

0.020

2.17

1.15–4.11

0.017

Hypertension (yes vs. no)

0.90

0.46–1.77

0.763

0.94

0.47–1.86

0.854

0.90

0.50–1.62

0.723

Cardiovascular disease (yes vs. no)

0.61

0.22–1.73

0.355

0.51

0.18–1.46

0.211

0.68

0.30–1.52

0.343

Metformin (yes vs. no)

0.77

0.34–1.75

0.531

0.79

0.33–1.90

0.595

1.22

0.62–2.40

0.563

Complete response (yes vs. no)

0.56

0.29–1.07

0.077

0.49

0.25–0.94

0.033

0.74

0.41–1.33

0.316

  1. Abbreviation: CI, confidence interval, HbA 1c hemoglobin A1c, HR hazard ratio, LVSI lymphatic vascular space invasion