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Table 3 Multivariate Cox analysis of prognostic factors associated with survival for patients with locally advanced cervical cancer who underwent neoadjuvant chemotherapy and radical hysterectomy

From: Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

 

Recurrence-free survival

Cancer-specific survival

Overall survival

 

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Age (years)

 Body mass index (kg/m2)

1.04

0.90–1.19

0.621

1.03

0.89–1.20

0.680

   

Serum creatinine (μmol/l)

 Tumor stage (IIA2 vs. IB2)

  Histology (non-squamous vs. squamous)

1.28

0.70–2.35

0.427

1.30

0.68–2.47

0.430

1.28

0.51–3.21

0.602

  Tumor differentiation (G3 vs. G1–2)

   

4.16

1.93–8.97

<0.0001

   

  Deep stromal invasion (yes vs. no)

0.77

0.40–1.49

0.433

0.83

0.42–1.63

0.586

1.21

0.68–2.16

0.516

  LVSI (yes vs. no)

1.26

0.73–2.15

0.405

1.16

0.66–2.04

0.616

0.91

0.56–1.48

0.708

  Positive margins (yes vs. no)

3.70

1.86–7.35

<0.0001

4.42

2.15–9.08

<0.0001

3.26

1.69–6.28

<0.0001

  Positive nodes (yes vs. no)

5.21

2.82–9.62

<0.0001

6.67

3.47–12.80

<0.0001

3.47

2.09–5.78

<0.0001

  Positive parametrium (yes vs. no)

3.37

1.67–6.82

0.001

3.14

1.54–6.41

0.002

2.84

1.41–5.73

0.004

Diabetes

 No

Reference

Reference

Reference

Reference

Reference

Reference

Reference

Reference

Reference

 HbA1c < 7%

1.49

0.69–3.22

0.307

1.57

0.68–3.62

0.290

2.06

1.04–4.07

0.039

 HbA1c ≥ 7%

3.33

1.89–5.88

<0.0001

3.60

1.96–6.61

<0.0001

4.35

2.64–7.17

<0.0001

Hypertension (yes vs. no)

 Cardiovascular disease (yes vs. no)

   

0.57

0.22–1.48

0.245

   

 Metformin (yes vs. no)

      

1.13

0.41–3.11

0.807

 Complete response (yes vs. no)

0.58

0.36–0.95

0.031

0.52

0.31–0.87

0.013

0.78

0.50–1.22

0.279

  1. Abbreviation: CI confidence interval, HbA 1c hemoglobin A1c, HR hazard ratio, LVSI lymphatic vascular space invasion