Novel approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer: a multi-centre observational study

Table 2 Schedule of procedures/evaluations in Acute Cohort

Procedure/Evaluation	Baseline (prior to starting anthracycline)	Study Visits prior to each anthracycline dose	3 months after completion of final anthracycline dose (± 4 weeks)	12 months after completion of final anthracycline dose (± 8 weeks)
Informed Consent/Assent	X
Demographics	X
Height (cm) & Weight (kg)	X	X	X	X
Concomitant Medications	X	X	X	X
Medical History	X
Review of Medical Events	X	X	X	X
Cancer Therapy		X	X
Echocardiogram (ECHO)	X	X^a		X
Genetic Sample	Obtain one sample at any time point while patient is on-study^%
OPTIONAL Biomarker Sample	X	X	X	X

^%For patients who will be having an allogeneic stem cell transplant, collect the genetic sample prior to the procedure
^aECHOs will be performed prior to each dose of anthracycline when possible. If patient/parent is not agreeable to research-only ECHOs, then they will occur only at clinically indicated time points

ISSN: 1471-2407