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Fig. 8 | BMC Cancer

Fig. 8

From: A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells

Fig. 8

Proposed pathways for the hydrolysis of EG22 and its dual PARP-DNA targeting property. Solid arrows describe hydrolysis and dotted arrows diffusion. EG22 may diffuse in its intact form through the cell membrane to subsequently hydrolyze in the cytoplasm, release ANI and the methyl diazonium species. ANI may then in turn diffuse into the nucleus and either intercalate into the DNA or inhibit PARP. EG22 may also diffuse in its intact form toward the nucleus, intercalate into DNA prior to being converted to ANI and the methyl diazonium species

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