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Fig. 4 | BMC Cancer

Fig. 4

From: A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells

Fig. 4

Hydrolysis of EG22 and ZSM02 in serum-containing medium. a The solution of EG22 was kept at 37 °C in the fluorescence reader and an intensity curve automatically generated at the maximum emission wavelength corresponding to ANI (538 nm) (t1/2 = 9.76 min); b ZSM02 was dissolved in a minimum volume of DMSO and diluted with DMEM supplemented with 10% FBS. The solution was incubated at 37 °C and 100 μL aliquots were analyzed by HPLC as described in Material and Methods. ZSM02 was slowly converted to ANI with t1/2 greater than 24 h

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BMC Cancer

ISSN: 1471-2407

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