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Fig. 2 | BMC Cancer

Fig. 2

From: Improved anticancer drug response prediction in cell lines using matrix factorization with similarity regularization

Fig. 2

Similar cell lines respond similarly to the similar drugs. a Lower triangular matrix containing Pearson correlation between each pair of gene expression profiles of cell lines. The X-axis and Y-axis represent cell lines classified by their cancer-types (TCGA classification). Box plots show the correlations of gene expression within the same and between different cancer-types. b Lower triangular matrix containing Pearson correlation between each pair of drug sensitivity profiles of cell lines. Box plots show the correlations of drug sensitivity within the same and between different cancer-types. c Box plots show the correlations of sensitivity profiles across cell lines within the same and between different drug clusters. The drugs were hierarchically clustered according to the similarity of their chemical fingerprints. The one-sided Mann–Whitney U test was used to measure the statistical difference between two groups

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