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Table 1 Risk adapted SRS dose prescription volume and location based

From: Whole brain radiotherapy versus stereotactic radiosurgery for 4–10 brain metastases: a phase III randomised multicentre trial

PTV of the largest brain metastasis

Doses in each PTV

BM in brainstem (GTV = PTV)

<1 cm3

1 × 24 Gy

1× 16Gy

1–10 cm3

1 × 21 Gy

1 x 16Gy

10–20 cm3

1 × 18 Gy

1 x 16Gy

20–65 cm3

1 × 15 Gy

No SRS

  1. All BMs are dosed equally in the same patient. If the V12 Gy exceeds 10 cm3 of the healthy brain tissue nearby the largest brain metastasis, it is allowed to lower the fraction dose to a single dose of 21, 18 or 15 Gy