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Table 1 Risk adapted SRS dose prescription volume and location based

From: Whole brain radiotherapy versus stereotactic radiosurgery for 4–10 brain metastases: a phase III randomised multicentre trial

PTV of the largest brain metastasis Doses in each PTV BM in brainstem (GTV = PTV)
<1 cm3 1 × 24 Gy 1× 16Gy
1–10 cm3 1 × 21 Gy 1 x 16Gy
10–20 cm3 1 × 18 Gy 1 x 16Gy
20–65 cm3 1 × 15 Gy No SRS
  1. All BMs are dosed equally in the same patient. If the V12 Gy exceeds 10 cm3 of the healthy brain tissue nearby the largest brain metastasis, it is allowed to lower the fraction dose to a single dose of 21, 18 or 15 Gy