From: Clinicopathological features and prognostic validity of WHO grading classification of SI-NENs
Factor (N) | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
 |  | 2% as threshold | 5% as threshold | |||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Age (207) | 1.02 (0.99–1.04) | 0.204 |  |  |  |  |
Sex | Â | 0.502 | Â | Â | Â | Â |
 Male (121) | 1.00 |  |  |  |  |  |
 Female (86) | 0.82 (0.45–1.48) |  |  |  |  | |
Location of primary tumor | ||||||
 Ampulla (54) | 1.00 |  |  |  |  |  |
 Non-ampulla duodenum (106) | 0.69 (0.35–1.34) | 0.272 |  |  |  | |
 Jejunum/ileum (47) | 0.62 (0.29–1.34) | 0.223 |  |  |  | |
Tumor stage | Â | 0.002 | Â | 0.022 | Â | 0.033 |
 Stage I/II (95) | 1.00 |  | 1.00 |  | 1.00 |  |
 Stage III (44) | 2.43 (1.01–5.87) | 0.048 | 1.89 (0.78–4.58) | 0.158 | 1.90 (0.79–4.61) | 0.155 |
 Stage IV (48) | 4.68 (2.13–10.27) | <0.001 | 3.44 (1.55–7.62) | 0.002 | 3.29 (1.48–7.31) | 0.003 |
 Unknown (20) | 2.90 (1.03–8.15) | 0.044 | 2.26 (0.80–6.37) | 0.124 | 2.17 (0.77–6.13) | 0.144 |
Ki-67 index | Â | <0.001 | Â | <0.001 | Â | Â |
  ≤ 2% (80) | 1.00 |  | 1.00 |  |  |  |
 3%–20% (63) | 2.67 (0.82–8.68) | 0.102 | 2.18 (0.66–7.15) | 0.199 |  | |
  > 20% (64) | 14.73 (5.20–41.74) | <0.001 | 12.21 (4.26–34.98) | <0.001 |  | |
Ki-67 index | Â | <0.001 | Â | Â | Â | <0.001 |
  ≤ 5% (118) | 1.00 |  |  |  | 1.00 |  |
 6%–20% (25) | 4.29 (1.44–12.76) | 0.009 |  |  | 3.28 (1.08–9.98) | 0.036 |
  > 20% (64) | 12.98 (5.70–29.56) | <0.001 |  |  | 11.31 (4.92–26.01) | <0.001 |