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Table 1 Comparison of the clinical characteristics of SI-NENs among different races

From: Clinicopathological features and prognostic validity of WHO grading classification of SI-NENs

Characteristics

Chinese Patients

(N = 277)

SEER database

P value

White patients (N = 6711)

Black patients (N = 1387)

Asian/Pacific Islander Patients (N = 217)

Age, years

    

<0.001

 Mean(95%CI)

54.4 (52.8–56.0)

62.4 (62.0–62.7)

60.3 (59.6–61.0)

60.7 (59.0–62.5)

 

 Range

17–83

2–98

21–96

27–95

Sex

    

<0.001

 Male

157 (56.7%)

3448 (51.4%)

635 (45.8%)

116 (53.5%)

 

 Female

120 (43.3%)

3263 (48.6%)

752 (54.2%)

101 (46.5%)

Location of primary tumora

    

<0.001

 Duodenum

212b (76.5%)

1541 (31.9%)

569 (57.5%)

123 (71.9%)

 

 ampulla

72 (37.1%)

117 (7.6%)

24 (4.2%)

9 (7.3%)

 Non-ampulla

122 (62.9%)

1424 (92.4%)

545 (95.8%)

114 (92.7%)

 Jejunum/ileum

65 (23.5%)

3283 (68.1%)

420 (42.5%)

48 (28.1%)

Presenting Symptoms

    

-

 Abdominal pain

152 (54.9%)

    

 Nausea/vomiting

48 (17.3%)

   

 Bloating

42 (15.2%)

   

 Jaundice

37 (13.4%)

   

 GI bleeding

34 (12.3%)

   

 Diarrhea

27 (9.7%)

   

 Intestinal obstruction

24 (8.7%)

   

 Flushing

9 (3.2%)

   

Incidental diagnosis

    

-

 Yes

35 (12.6%)

    

 No (symptomatic)

242 (87.4%)

   

Tumor sizec

    

<0.001

 Median (cm)

2.5

1.6

1.5

1.5

 

Tumor graded

    

-

 Grade 1

91 (36.5%)

    

 Grade 2

81 (32.5%)

   

 Grade 3

77 (30.9%)

   

Tumor differentiatione

    

0.095f

 Well differentiated

 

2324 (76.6%)

474 (81.3%)

69 (74.2%)

 

 Moderately differentiated

 

553 (18.2%)

84 (14.4%)

15 (16.1%)

 Poorly differentiated/undifferentiated

 

157 (5.2%)

25 (4.3%)

9 (9.7%)

Tumor stageg

    

<0.001h

 I

32 (13.3%)

626 (13.2%)

162 (18.3%)

43 (25.4%)

 

 II

88 (36.5%)

709 (15.0%)

186 (21.0%)

28 (16.6%)

 III

61 (25.3%)

2077 (43.8%)

331 (37.4%)

59 (34.9%)

 IV

60 (24.9%)

1329 (28.0%)

205 (23.2%)

39 (23.1%)

Location of distant metastasesi

    

-

 No

217 (78.3%)

    

 Liver

52 (86.7%)

   

 Bone

3 (5.0%)

   

 Lung

1 (1.7%)

   

 Brain

1 (1.7%)

   

 Others

13 (21.7%)

   

Surgery of primary tumor

    

-

 Performed

233 (84.1%)

5787 (86.2%)

1097 (79.1%)

166 (76.5%)

 

 Unperformed or unknown

44 (15.9%)

924 (13.8%)

290 (20.9%)

51 (23.5%)

 
  1. GI gastrointestinal. aThe specific location of 1887 white patients, 398 black patients and 46 Asian/Pacific Islander patients from SEER database were not available. bIn Chinese patients, the specific location of 18 patients with duodenal NENs was unknown. cTumor size was specified in 222 Chinese patients, 5249 white patients, 1008 black patients and 151 Asian/Pacific Islander patients from SEER database. dTumor grade based on WHO grading criteria was specified in 249 Chinese patients. eIn SEER database series, tumor differentiation was available in 3034 white patients, 583 black patients and 93 Asian/Pacific Islander patients. fWell/moderately differentiated and poorly differentiated/undifferentiated were compared among different races. gTumor stage was specified in 241 Chinese patients, 4741 white patients, 884 black patients and 169 Asian/Pacific Islander patients from SEER database. hStage I/II and stage III/IV were compared among different races. iInformation of location of distant metastases was available in all Chinese patients
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BMC Cancer

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