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Table 2 Association among gene polymorphisms and risk of severe toxicity (grade 3–4 vs. 0–1-2)

From: Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy

  HEMATOLOGIC TOXICITY NON-HEMATOLOGIC TOXICITY
LEUCOPENIA NEUTROPENIA STOMATITIS HEPATIC
Genotype 0–1-2 3–4 OR (95%CI) p 0–1-2 3–4 OR (95%CI) P 0–1-2 3–4 OR (95%CI) p 0–1-2 3–4 OR (95%CI) p
GSTT1
 null 47 3 1 (reference) 0.155 45 5 1 (reference) 0.349 49 1 1 (reference) 0.822 49 1 1 (reference) 0.335
 Present 190 4 0.33 (0.07–1.52) 182 12 0.59 (0.30–1.77) 191 3 0.77 (0.08–7.56) 193 1 0.25(0.02–4.13)
GSTM1
 null 129 3 1 (reference) 0.548 122 10 1 (reference)   131 1 a 132 0 a
 Present 108 4 1.59 (0.35–7.27) 105 7 0.81 (0.30–2.21) 0.686 109 3 110 2
GSTP1
 AA 141 4 1 (reference) 0.832 134 11 1 (reference) 0.150 142 3 1 (reference) 0.569 144 1 a
 AG 91 3 1.18 (0.26–5.39) 89 5 0.70 (0.23–2.07) 93 1 0.52 (0.05–5.04) 93 1
 GG 3 0   2 1   3 0   3 0
RCF1
 GG 71 3 1 (reference) 0.598 69 5 1 (reference) 0.759 73 1 1 (reference) 0.824 74 0 a
 GA 110 3 0.64 (0.13–3.29) 104 9 1.19 (0.38–3.72) 111 2 1.32 (0.12–14.8) 113 0
 AA 56 1 0.42 (0.04–4.17) 0.461 54 3 0.77 (0.18–3.35) 0.724 56 1 1.30 (0.08–21.3) 0.852 55 2
 AA vs. GA + GG 0.54 (0.06–4.57) 0.571 0.69 (0.19–2.48) 0.566 1.10 (0.11–10.74) 0.938  
MTHFR
 CC 64 1 1 (reference)   66 1 1 (reference)   67 0 a 67 0 a
 CT 113 3 0.57 (0.11–2.89) 0.494 103 13 8.32 (1.06–65.2) 0.043 114 2 115 1
 TT 60 1 0.36 (0.04–3.51) 0.376 58 3 3.41 (0.35–33.7) 0.294 59 2 60 1
 TT vs. CT + CC 0.49 (0.06–4.17) 0.515 0.62 (0.17–2.25) 0.472 3.07 (0.42–22.3) 0.268  
TS-TR
 2R/2R 84 2 1 (reference)   83 3 1 (reference)   85 1 1 (reference)   86 0 a
 2R/3R 74 4 0.44 (0.08–2.47) 0.352 68 10 0.25 (0.06–0.93) 0.038 76 2 0.45 (0.04–5.03) 0.514 78 0
 3R/3R 79 1 0.23 (0.03–2.14) 0.199 76 4 0.36 (0.11–1.19) 0.095 79 1 0.48 (0.04–5.42) 0.553 78 2
 3/3R vs. 2/3R + 2/2R 0.33 (0.04–2.82) 0.313 0.61 (0.19–1.94) 0.403 0.68 (0.07–6.64) 0.740  
  1. OR Odds Ratio, CI Confidence Intervals
  2. aDue to the low number of events it was not always possible to perform the comparison test