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Table 1 Baseline characteristics of patients

From: Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy

Characteristics

No. of patients (%)

All patients

244 (100)

Median age, years (min-max)

51.3 (26.6–75.6)

Stage

 I

111 (45.5)

 II

93 (38.1)

 III

40 (16.4)

Tumor size, ≤2 cm

49 (34.0)

Positive lymph nodes status

107 (43.9)

Tumor grade

 G1

18 (7.4)

 G2

143 (58.6)

 G3

59 (24.2)

 Unknown

24 (9.8)

Histology

 Ductal infiltrating carcinoma

212 (86.9)

 Other histology

32 (14.1)

Positive ER status (cut-off > 10%)

154 (63.1)

Positive PgRstatus(cut-off > 10%)

137 (56.1)

Ki67 positive status(cut-off > 14%)

112 (45.9)

Positive p53 status(cut-off ≥ 1%)

34 (13.9)

Positive HER2a(IHC/FISH)

26 (10.7)

Surgery

 Conservative

201 (82.4)

 Mastectomy

43 (17.6)

Adjuvant chemotherapy

 CMF

124 (50.8)

 FEC

120 (49.2)

Endocrine therapy

148 (60.6)

Radiotherapy

205 (84.0)

  1. aIHC 3 + or IHC 2+ and FISH amplified
  2. ER estrogen receptor; PgR, progesterone receptor
  3. CMF cyclophosphamide, methotrexate, 5-fluorouracil
  4. FEC 5-fluorouracil, epirubicin, cyclophosphamide