Fig. 8

Cellular distribution of CNKSR1 is associated with p-ERK expression levels in pancreatic cancer specimens. a p-ERK cellular distribution and nuclear expression levels (scored as 1+, 2+, and 3+) in 86 cases of the SEER Pancreatic Cancer TMA. b Nuclear expression levels of p-ERK (scored as 1+, 2+, and 3+) are not associated with presence of cytoplasmic p-ERK expression pattern. c Pancreatic cancer specimens with concomitant cytoplasmic and nuclear CNKSR1 expression have increased nuclear p-ERK staining (scored by 0, 1+, 2+, and 3+ intensity levels) compared to pancreatic cancers with cytoplasmic CNKSR1 staining only (Mann Whitney U test; 2-tailed). d Cytoplasmic CNKSR1 expression levels (scored semiquantitatively as 0, 1+, 2+, and 3+) and nuclear p-ERK expression levels (scored as % positive cells) (Pearson’s correlation coefficient test; 2-tailed). e Kaplan-Meier survival analysis of pancreatic cancer cases from SEER Pancreatic Cancer TMA with p-ERK stratified by cellular distribution of p-ERK (nuclear vs nuclear and cytoplasmic) (log-rank; 2-tailed)