Fig. 4

ROCK2 knockdown results in reduced proliferation in a xenograft vascular tumor model. a Histogram depicting immunopositivity for Ki67 in scrambled control and ROCK2 knockdown xenograft vascular tumors. Data presented is the mean plus or minus the standard deviation. Asterisks indicate p value <0.005. b Representative images of scrambled control (a) and ROCK2 knockdown (b) angiosarcoma tumors stained via immunohistochemistry for the proliferative marker Ki67 (immunopositivity is brown). Positive control (c) is Ki67 staining of a breast carcinoma and negative control (d) is the xenograft vascular tumor minus primary antibody incubation. Please see Additional file 6 for high resolution image