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Fig. 3 | BMC Cancer

Fig. 3

From: Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth

Fig. 3

ROCK1 & 2 knockdowns in a xenograft vascular tumor model. a qPCR quantification of the levels of ROCK1 and ROCK2 mRNA in the SVR xenograft tumors relative to the scrambled control. GAPDH mRNA was used as a normalization control for RQ calculations. For statistical analysis, the Student’s t-test was used. Statistical significance was determined if the two-sided P value of the test was <0.05. b Representative images of mice harboring subcutaneous scrambled control, ROCK1 shRNA, and ROCK2 shRNA vascular xenograft tumors. c Box and whisker plot showing the distribution of tumor weights in scrambled control, ROCK1 shRNA and ROCK2 shRNA vascular xenograft tumors. Asterisks indicate p value <0.0005. (d) Low magnification H&E staining of whole tumor sections showing relative tumor sizes following removal from the host. Please see Additional file 5 for high resolution image

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