Table 1 Literature review of all clinical cases to date
Authors | Age (y) | Sex | Method of diagnosis and/or type of tissue sampled | ALK detection | Smoking history (pack-years) | Prior treatment | ALK inhibitor | Efficacy |
|---|---|---|---|---|---|---|---|---|
Wang et al. [9] | 55 | F | Biopsy of the cervical lymph node | IHC, FISH | Non-smoker | PDC | Crizotinib | PR |
Mikes et al. [10] | 36 | M | Bronchial biopsy of the primary lesion | IHC, FISH, RT-PCR | Non-smoker | None | Crizotinib | PR |
Zhang et al. [11] | 55 | F | Bronchial biopsy of the primary lesion | IHC | Non-smoker | PDC | Crizotinib | PR |
Vergne et al. [12] | 58 | F | Bronchial biopsy | IHC, FISH | Non-smoker | PDC | Crizotinib | PR |
Tamiya et al. [13] | 78 | M | Primary lesion | IHC, FISH | 49 | None | Alectinib | PD |
This case | 52 | F | Bronchial biopsy of the mediastinal lymph node | IHC, FISH | Non-smoker | PDC | Alectinib | PR |