Table 2 Univariate and multivariate analyses for the relapse-free survival of patients with ICC
Variables | n (%) | Relapse-free survival (%) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|
1-year | 3-year | 5-year | HR (95% CI) | P value | HR (95% CI) | P value | ||
Age | ||||||||
> 60 years | 50 (47.2) | 36.0 | 15.6 | 11.6 | 1.302 (0.827-2.049) | 0.253 | NA | NA |
≤ 60 years | 56 (52.8) | 42.9 | 25.0 | 9.8 | ||||
Gender | ||||||||
Male | 62 (58.5) | 38.7 | 17.0 | 10.0 | 1.129 (0.711-1.793) | 0.608 | NA | NA |
Female | 44 (41.5) | 40.9 | 25.0 | 11.8 | ||||
HBV infection | ||||||||
HBsAg | ||||||||
Present | 30 (28.2) | 63.3 | 44.0 | 25.0 | 0.424 (0.239-0.751) | 0.002 | 0.505 (0.279-0.914) | 0.024 |
Absent | 76 (71.8) | 30.3 | 11.8 | 6.3 | ||||
HBsAg-negative | ||||||||
HBcAb-positive | ||||||||
Present | 12 (11.3) | 41.7 | 0 | 0 | 0.734 (0.348-1.549) | 0.415 | NA | NA |
Absent | 94 (88.7) | 30.0 | 15.0 | 8.9 | ||||
Liver cirrhosis | ||||||||
Present | 25 (23.6) | 44.0 | 15.0 | 5.6 | 0.888 (0.517-1.526) | 0.668 | NA | NA |
Absent | 81 (76.4) | 38.3 | 21.9 | 12.1 | ||||
Preoperative AFP | ||||||||
> 9 ng/ml | 28 (26.4) | 39.3 | 33.3 | 20.8 | 0.889 (0.527-1.499) | 0.658 | NA | NA |
≤ 9 ng/ml | 78 (73.6) | 39.7 | 15.2 | 6.7 | ||||
Preoperative CA19-9 | ||||||||
> 35 U/ml | 73 (68.9) | 34.2 | 14.3 | 9.8 | 1.499 (0.897-2.504) | 0.119 | NA | NA |
≤ 35 U/ml | 33 (31.1) | 51.5 | 33.3 | 13.0 | ||||
Hepatectomy | ||||||||
Minor | 48 (45.3) | 47.9 | 26.3 | 15.2 | 1.560 (0.975-2.494) | 0.061 | NA | NA |
Major | 58 (54.7) | 32.8 | 16.4 | 7.8 | ||||
Tumor size | ||||||||
> 5 cm | 61 (57.5) | 26.2 | 12.5 | 5.7 | 2.044 (1.258-3.321) | 0.003 | 1.947 (1.177-3.219) | 0.009 |
≤ 5 cm | 45 (42.5) | 57.8 | 32.4 | 19.4 | ||||
Tumor number | ||||||||
Single | 89 (84.0) | 43.8 | 23.7 | 13.2 | 1.752 (1.002-3.064) | 0.046 | NS | NS |
Multiple | 17 (16.0) | 17.6 | 5.9 | 0 | ||||
Child-Pugh score | ||||||||
A | 100 (94.3) | 41.0 | 21.8 | 11.5 | 2.698 (1.158-6.282) | 0.017 | 3.067 (1.293-7.275) | 0.011 |
B | 6 (5.7) | 16.7 | 0 | 0 | ||||
Histology | ||||||||
Well or moderate | 52 (49.1) | 46.2 | 18.2 | 9.8 | 1.084 (0.689-1.706) | 0.727 | NA | NA |
Poor | 54 (50.9) | 33.3 | 22.4 | 11.6 | ||||
Vascular invasion | ||||||||
Present | 28 (26.4) | 35.7 | 12.0 | 4.3 | 1.286 (0.782-2.116) | 0.321 | NA | NA |
Absent | 78 (73.6) | 41.0 | 23.5 | 13.1 | ||||
Lymph node metastasis | ||||||||
Present | 48 (45.3) | 18.8 | 2.2 | 0 | 2.816 (1.747-4.538) | < 0.001 | 2.790 (1.628-4.781) | < 0.001 |
Absent | 58 (54.7) | 56.9 | 37.5 | 22.5 | ||||