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Table 2 Univariate and multivariate analyses for the relapse-free survival of patients with ICC

From: Risk stratification system to predict recurrence of intrahepatic cholangiocarcinoma after hepatic resection

Variables n (%) Relapse-free survival (%) Univariate analysis Multivariate analysis
1-year 3-year 5-year HR (95% CI) P value HR (95% CI) P value
Age
 > 60 years 50 (47.2) 36.0 15.6 11.6 1.302 (0.827-2.049) 0.253 NA NA
 ≤ 60 years 56 (52.8) 42.9 25.0 9.8     
Gender
 Male 62 (58.5) 38.7 17.0 10.0 1.129 (0.711-1.793) 0.608 NA NA
 Female 44 (41.5) 40.9 25.0 11.8     
HBV infection
 HBsAg
  Present 30 (28.2) 63.3 44.0 25.0 0.424 (0.239-0.751) 0.002 0.505 (0.279-0.914) 0.024
  Absent 76 (71.8) 30.3 11.8 6.3     
HBsAg-negative
HBcAb-positive
 Present 12 (11.3) 41.7 0 0 0.734 (0.348-1.549) 0.415 NA NA
 Absent 94 (88.7) 30.0 15.0 8.9     
Liver cirrhosis
 Present 25 (23.6) 44.0 15.0 5.6 0.888 (0.517-1.526) 0.668 NA NA
 Absent 81 (76.4) 38.3 21.9 12.1     
Preoperative AFP
 > 9 ng/ml 28 (26.4) 39.3 33.3 20.8 0.889 (0.527-1.499) 0.658 NA NA
 ≤ 9 ng/ml 78 (73.6) 39.7 15.2 6.7     
Preoperative CA19-9
 > 35 U/ml 73 (68.9) 34.2 14.3 9.8 1.499 (0.897-2.504) 0.119 NA NA
 ≤ 35 U/ml 33 (31.1) 51.5 33.3 13.0     
Hepatectomy
 Minor 48 (45.3) 47.9 26.3 15.2 1.560 (0.975-2.494) 0.061 NA NA
 Major 58 (54.7) 32.8 16.4 7.8     
Tumor size
 > 5 cm 61 (57.5) 26.2 12.5 5.7 2.044 (1.258-3.321) 0.003 1.947 (1.177-3.219) 0.009
 ≤ 5 cm 45 (42.5) 57.8 32.4 19.4     
Tumor number
 Single 89 (84.0) 43.8 23.7 13.2 1.752 (1.002-3.064) 0.046 NS NS
 Multiple 17 (16.0) 17.6 5.9 0     
Child-Pugh score
 A 100 (94.3) 41.0 21.8 11.5 2.698 (1.158-6.282) 0.017 3.067 (1.293-7.275) 0.011
 B 6 (5.7) 16.7 0 0     
Histology
 Well or moderate 52 (49.1) 46.2 18.2 9.8 1.084 (0.689-1.706) 0.727 NA NA
 Poor 54 (50.9) 33.3 22.4 11.6     
Vascular invasion
 Present 28 (26.4) 35.7 12.0 4.3 1.286 (0.782-2.116) 0.321 NA NA
 Absent 78 (73.6) 41.0 23.5 13.1     
Lymph node metastasis
 Present 48 (45.3) 18.8 2.2 0 2.816 (1.747-4.538) < 0.001 2.790 (1.628-4.781) < 0.001
 Absent 58 (54.7) 56.9 37.5 22.5     
  1. HR hazard ratio, CI confidence interval, NA not applicable, HBV hepatitis B virus, HBsAg hepatitis B surface antigen, HBcAb hepatitis B core antibody, AFP alpha fetoprotein, CA19-9 carbohydrate antigen 19-9, NS not significant