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Table 6 Pathways from the National Cancer Institute-Nature Pathway Interaction Database overrepresented in RC-77 cell lines

From: Proteomic characterization of paired non-malignant and malignant African-American prostate epithelial cell lines distinguishes them by structural proteins

Pathway Name Differentially Expressed Proteins in Pathway p-value q-value
α6β1 and α6β4 integrin signaling ITGA6, ITGB1, LAMC2, SFN 5.75E-05 7.88E-03
α4β7 integrin signaling CD44, ITGB1 7.79E-04 5.14E-02
α6β4 integrin-ligand interactions ITGA6, LAMC2 1.18E-03 5.14E-02
Arf6 trafficking events CTNNB1, ITGA6, ITGB1 1.50E-03 5.14E-02
TGF-beta receptor signaling CAV1, CTNNB1, PML* 2.08E-03 5.70E-02
mTOR signaling pathway EIF4B, PML*, SFN 4.07E-03 7.38E-02
β1 integrin cell surface interactions ITGA6, ITGB1, LAMC2 4.07E-03 7.38E-02
Canonical Wnt signaling pathway CAV1, CTNNB1 4.31E-03 7.38E-02
Plexin-D1 signaling ITGA6, ITGB1 5.59E-03 8.51E-02
Integrin family cell surface interactions ITGA6, ITGB1 6.52E-03 8.93E-02
BARD1 signaling events EWSR1*, XRCC5 8.58E-03 1.07E-01
Syndecan-4-mediated signaling events ACTN1, ITGB1 9.69E-03 1.11E-01
Signaling mediated by p38-alpha and p38-beta KRT19, KRT8 1.34E-02 1.40E-01
E-cadherin signaling events CTNNB1 1.43E-02 1.40E-01
Stabilization and expansion of the E-cadherin adherens junction ACTN1, CTNNB1 1.75E-02 1.60E-01
Integrin-linked kinase signaling ACTN1, CTNNB1 1.90E-02 1.63E-01
FoxO family signaling CTNNB1, SFN 2.21E-02 1.78E-01
Direct p53 effectors CAV1, PML*, SFN 2.46E-02 1.87E-01
Caspase cascade in apoptosis LMNB1, VIM 2.79E-02 2.01E-01
Co-regulation of androgen receptor activity CTNNB1, XRCC5 3.32E-02 2.17E-01
Signaling events mediated by focal adhesion kinase ACTN1, ITGB1 3.32E-02 2.17E-01
Validated targets of C-MYC transcriptional repression ITGA6, ITGB1 4.27E-02 2.54E-01
Signaling events mediated by VEGFR1 and VEGFR2 CAV1, CTNNB1 4.27E-02 2.54E-01
p73 transcription factor network PML*, SFN 4.88E-02 2.79E-01
  1. Proteins in bold font were upregulated in RC-77 T/E. Proteins in italic font were downregulated in RC-77 T/E. *Protein found in RC-77 T/E only. P-values were calculated using a hypergeometric cumulative distribution function. Q-value is the p-value corrected for multiple hypotheses testing using the Benjamini-Hochberg method. ACTN1 alpha-actinin-1, CAV1 caveolin-1, CD44 CD44 antigen, CTNNB1 beta-catenin, EIF4B eukaryotic translation initiation factor 4B, EWSR1 RNA-binding protein EWS, ITGA6 integrin alpha-6, ITGB1 integrin beta-1, KRT8 type II cytoskeletal keratin 8, KRT19 = type I cytoskeletal keratin 19, LAMC2 laminin subunit gamma-2, LMNB1 lamin-B1, PML protein PML, SFN 14–3-3 protein sigma, VIM vimentin, XRCC5 X-ray repair cross-complementing protein 5