Table 6 Pathways from the National Cancer Institute-Nature Pathway Interaction Database overrepresented in RC-77 cell lines
Pathway Name | Differentially Expressed Proteins in Pathway | p-value | q-value |
|---|---|---|---|
α6β1 and α6β4 integrin signaling | ITGA6, ITGB1, LAMC2, SFN | 5.75E-05 | 7.88E-03 |
α4β7 integrin signaling | CD44, ITGB1 | 7.79E-04 | 5.14E-02 |
α6β4 integrin-ligand interactions | ITGA6, LAMC2 | 1.18E-03 | 5.14E-02 |
Arf6 trafficking events | CTNNB1, ITGA6, ITGB1 | 1.50E-03 | 5.14E-02 |
TGF-beta receptor signaling | CAV1, CTNNB1, PML* | 2.08E-03 | 5.70E-02 |
mTOR signaling pathway | EIF4B, PML*, SFN | 4.07E-03 | 7.38E-02 |
β1 integrin cell surface interactions | ITGA6, ITGB1, LAMC2 | 4.07E-03 | 7.38E-02 |
Canonical Wnt signaling pathway | CAV1, CTNNB1 | 4.31E-03 | 7.38E-02 |
Plexin-D1 signaling | ITGA6, ITGB1 | 5.59E-03 | 8.51E-02 |
Integrin family cell surface interactions | ITGA6, ITGB1 | 6.52E-03 | 8.93E-02 |
BARD1 signaling events | EWSR1*, XRCC5 | 8.58E-03 | 1.07E-01 |
Syndecan-4-mediated signaling events | ACTN1, ITGB1 | 9.69E-03 | 1.11E-01 |
Signaling mediated by p38-alpha and p38-beta | KRT19, KRT8 | 1.34E-02 | 1.40E-01 |
E-cadherin signaling events | CTNNB1 | 1.43E-02 | 1.40E-01 |
Stabilization and expansion of the E-cadherin adherens junction | ACTN1, CTNNB1 | 1.75E-02 | 1.60E-01 |
Integrin-linked kinase signaling | ACTN1, CTNNB1 | 1.90E-02 | 1.63E-01 |
FoxO family signaling | CTNNB1, SFN | 2.21E-02 | 1.78E-01 |
Direct p53 effectors | CAV1, PML*, SFN | 2.46E-02 | 1.87E-01 |
Caspase cascade in apoptosis | LMNB1, VIM | 2.79E-02 | 2.01E-01 |
Co-regulation of androgen receptor activity | CTNNB1, XRCC5 | 3.32E-02 | 2.17E-01 |
Signaling events mediated by focal adhesion kinase | ACTN1, ITGB1 | 3.32E-02 | 2.17E-01 |
Validated targets of C-MYC transcriptional repression | ITGA6, ITGB1 | 4.27E-02 | 2.54E-01 |
Signaling events mediated by VEGFR1 and VEGFR2 | CAV1, CTNNB1 | 4.27E-02 | 2.54E-01 |
p73 transcription factor network | PML*, SFN | 4.88E-02 | 2.79E-01 |