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Table 3 Categorization of differentially expressed proteins according to Gene Ontology Molecular Function

From: Proteomic characterization of paired non-malignant and malignant African-American prostate epithelial cell lines distinguishes them by structural proteins

Gene Ontology Molecular Function Annotation (Number of Differentially Expressed Proteins)

Binding Proteins (21)

• eukaryotic translation initiation factor 4B

• RNA-binding protein EWS

• high mobility group protein HMG-I/HMG-Y

• double-stranded RNA-specific adenosine deaminase

• plasminogen activator inhibitor 1 RNA-binding protein

• non-histone chromosomal protein HMG-17

• alpha-actinin-1

• nucleolar RNA helicase 2

• 60S ribosomal protein L35

• hepatoma-derived growth factor

• gamma-interferon-inducible protein 16

• 60S ribosomal protein L10

• PDZ and LIM domain protein 1

• non-histone chromosomal protein HMG-14

• high mobility group protein HMGI-C

• caveolin-1

• calpastatin

• beta-catenin

• 60S ribosomal protein L6

• filamin-A

• myosin heavy chain-9

Catalytic Activity Proteins (21)

• serotransferrin

• aminopeptidase N

• calpastatin

• double-stranded RNA-specific adenosine deaminase

• putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

• type I cytoskeletal high mobility group protein HMG-I/HMG-Y

• cytosolic acyl coenzyme A thioester hydrolase

• hydroxyacyl-coenzyme A dehydrogenase

• S-formylglutathione hydrolase

• phosphoenolpyruvate carboxykinase

• cytochrome c oxidase subunit 5A

• S-methyl-5′-thioadenosine phosphorylase

• creatine kinase U-type

• 60S ribosomal protein L35

• caveolin-1

• myosin heavy chain-9

• adenosylhomocysteinase

• nucleolar RNA helicase 2

• high mobility group protein HMGI-C

• phosphoserine aminotransferase

• RNA-binding protein EWS

Structural Molecule Activity (13)

• filamin-A

• 60S ribosomal protein L10

• 60S ribosomal protein L35

• Type I cytoskeletal keratin 19

• type II cytoskeletal keratin 8

• PDZ and LIM domain protein 1

• Myosin heavy chain-9

• 60S ribosomal protein L6

• 40S ribosomal protein S11

• alpha-actinin-1

• vimentin

• lamin-B1

• caveolin-1