Table 1 Differentially expressed proteins between RC-77 T/E and RC-77 N/E cell lines
Identified Proteins (Gene Symbol) | p-value | q-value | Log2 Fold Change | Status in RC-77 T/E Cells | Significant Pathway or Gene Set Involvement |
|---|---|---|---|---|---|
CD166 antigen (ALCAM) | 5.90E-04 | 4.91E-02 | −2.12 | Downregulated | |
*Caveolin-1 (CAV1) | 2.98E-04 | 4.91E-02 | −1.72 | Downregulated | Focal Adhesion; Proteoglycans in Cancer |
*Vimentin (VIM) | 4.09E-04 | 4.91E-02 | −1.61 | Downregulated | |
*Myosin heavy chain-9 (MYH9) | 4.04E-04 | 4.91E-02 | 1.58 | Upregulated | |
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) | 2.68E-04 | 4.91E-02 | 2.70 | Upregulated | |
Eukaryotic translation initiation factor 4B (EIF4B) | 5.78E-04 | 4.91E-02 | 2.77 | Upregulated | |
Calpastatin (CAST) | 3.55E-04 | 4.91E-02 | 3.09 | Upregulated | |
Nucleolar RNA helicase 2 (DDX21) | 4.16E-04 | 4.91E-02 | 3.20 | Upregulated | |
Creatine kinase U-type (CKMT1A) | 3.36E-04 | 4.91E-02 | 3.46 | Upregulated | |
Thioredoxin domain-containing protein 17 (TXNDC17) | 4.92E-04 | 4.91E-02 | 1.69 | RC-77 T/E only | |
*Type I cytoskeletal keratin 19 (KRT19) | 7.77E-04 | 5.40E-02 | −2.49 | Downregulated | |
Serotransferrin (TF) | 7.29E-04 | 5.40E-02 | −2.30 | Downregulated | |
Integrin alpha-6 (ITGA6) | 1.44E-03 | 5.40E-02 | −1.93 | Downregulated | Cell Adhesion Molecules; ECM-Receptor Interaction; Small Cell Lung Cancer |
Laminin subunit gamma-2 (LAMC2) | 9.86E-04 | 5.40E-02 | −1.72 | Downregulated | ECM-Receptor Interaction; Small Cell Lung Cancer; Focal Adhesion |
CD59 glycoprotein (CD59) | 9.15E-04 | 5.40E-02 | −1.65 | Downregulated | |
Squalene synthase (FDFT1) | 1.23E-03 | 5.40E-02 | −1.31 | Downregulated | |
*Filamin-A (FLNA) | 1.06E-03 | 5.40E-02 | 1.21 | Upregulated | Focal Adhesion, Proteoglycans in Cancer |
Hydroxyacyl-coenzyme A dehydrogenase (HADH) | 1.61E-03 | 5.40E-02 | 1.22 | Upregulated | |
X-ray repair cross-complementing protein 5 (XRCC5) | 1.42E-03 | 5.40E-02 | 1.35 | Upregulated | |
Prothymosin alpha (PTMA) | 1.49E-03 | 5.40E-02 | 1.65 | Upregulated | |
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) | 1.37E-03 | 5.40E-02 | 1.74 | Upregulated | |
High mobility group protein HMG-I/HMG-Y (HMGA1) | 1.58E-03 | 5.40E-02 | 1.79 | Upregulated | |
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (DHX15) | 1.10E-03 | 5.40E-02 | 2.10 | Upregulated | |
Scaffold attachment factor B1 (SAFB) | 1.59E-03 | 5.40E-02 | 2.27 | Upregulated | |
Nucleoprotein TPR (TPR) | 1.62E-03 | 5.40E-02 | 3.52 | Upregulated | |
Hemoglobin subunit alpha (HBA1) | 1.80E-03 | 5.54E-02 | −1.87 | RC-77 N/E only | |
Protein PML (PML) | 1.77E-03 | 5.54E-02 | 1.69 | RC-77 T/E only | |
Ribosome-binding protein 1 (RRBP1) | 1.89E-03 | 5.63E-02 | 1.64 | Upregulated | |
Adenosylhomocysteinase (AHCY) | 2.00E-03 | 5.75E-02 | 1.68 | Upregulated | |
Gamma-interferon-inducible protein 16 (IFI16) | 2.37E-03 | 6.59E-02 | 1.39 | Upregulated | |
Phosphoenolpyruvate carboxykinase (PCK2) | 2.51E-03 | 6.75E-02 | 3.04 | Upregulated | |
14–3-3 protein sigma (SFN) | 2.60E-03 | 6.76E-02 | 1.49 | Upregulated | |
*Lamin-B1 (LMNB1) | 3.04E-03 | 7.26E-02 | −0.87 | Downregulated | |
*Alpha-actinin-1 (ACTN1) | 3.05E-03 | 7.26E-02 | 1.06 | Upregulated | Tight Junction; Adherens Junction; Hippo Signaling Pathway; Focal Adhesion |
High mobility group protein HMGI-C (HMGA2) | 2.95E-03 | 7.26E-02 | 2.19 | Upregulated | |
Voltage-dependent anion-selective channel protein 1 (VDAC1) | 4.59E-03 | 7.67E-02 | −1.00 | Downregulated | |
Integrin beta-1 (ITGB1) | 3.48E-03 | 7.67E-02 | −0.92 | Downregulated | Cell Adhesion Molecules; ECM-Receptor Interaction; Small Cell Lung Cancer |
Non-histone chromosomal protein HMG-17 (HMGN2) | 4.22E-03 | 7.67E-02 | 1.34 | Upregulated | |
*PDZ and LIM domain protein 1 (PDLIM1) | 4.40E-03 | 7.67E-02 | 1.61 | Upregulated | |
T-complex protein 1 subunit epsilon (CCT5) | 4.72E-03 | 7.67E-02 | 1.66 | Upregulated | |
Aminopeptidase N (ANPEP) | 5.25E-03 | 7.67E-02 | −2.38 | RC-77 N/E only | |
Prefoldin subunit 2 (PFDN2) | 4.96E-03 | 7.67E-02 | 1.35 | RC-77 T/E only | |
40S ribosomal protein S24 (RPS24) | 4.96E-03 | 7.67E-02 | 1.35 | RC-77 T/E only | |
Serine/arginine-rich splicing factor 1 (SRSF1) | 4.96E-03 | 7.67E-02 | 1.35 | RC-77 T/E only | |
S-formylglutathione hydrolase (ESD) | 5.05E-03 | 7.67E-02 | 1.42 | RC-77 T/E only | |
RNA-binding protein EWS (EWSR1) | 5.15E-03 | 7.67E-02 | 1.47 | RC-77 T/E only | |
Hepatoma-derived growth factor (HDGF) | 5.15E-03 | 7.67E-02 | 1.47 | RC-77 T/E only | |
Non-histone chromosomal protein HMG-14 (HMGN1) | 4.96E-03 | 7.67E-02 | 1.47 | RC-77 T/E only | |
S-methyl-5′-thioadenosine phosphorylase (MTAP) | 4.96E-03 | 7.67E-02 | 1.47 | RC-77 T/E only | |
Phosphoserine aminotransferase (PSAT1) | 5.15E-03 | 7.67E-02 | 1.53 | RC-77 T/E only | |
60S ribosomal protein L10 (RPL10) | 4.99E-03 | 7.67E-02 | 1.53 | RC-77 T/E only | |
Proteasome activator complex subunit 3 (PSME3) | 5.22E-03 | 7.67E-02 | 1.58 | RC-77 T/E only | |
40S ribosomal protein S11 (RPS11) | 4.99E-03 | 7.67E-02 | 1.64 | RC-77 T/E only | |
tRNA-splicing ligase RtcB homolog (RTCB) | 5.25E-03 | 7.67E-02 | 1.64 | RC-77 T/E only | |
Double-stranded RNA-specific adenosine deaminase (ADAR) | 5.25E-03 | 7.67E-02 | 1.92 | RC-77 T/E only | |
Eukaryotic translation initiation factor 3 subunit I (EIF3I) | 5.22E-03 | 7.67E-02 | 1.96 | RC-77 T/E only | |
60S ribosomal protein L35 (RPL35) | 5.18E-03 | 7.67E-02 | 2.08 | RC-77 T/E only | |
Cytochrome c oxidase subunit 5A (COX5A) | 5.74E-03 | 8.24E-02 | −1.38 | Downregulated | |
*Beta-catenin (CTNNB1) | 5.93E-03 | 8.37E-02 | 1.40 | Upregulated | Tight Junction; Adherens Junction; Hippo Signaling Pathway; Focal Adhesion |
*Type II cytoskeletal keratin 8 (KRT8) | 6.14E-03 | 8.52E-02 | −1.79 | Downregulated | |
CD44 antigen (CD44) | 6.44E-03 | 8.60E-02 | −0.77 | Downregulated | Proteoglycans in Cancer; ECM-Receptor Interaction |
Plasminogen activator inhibitor 1 RNA-binding protein (SERBP1) | 6.51E-03 | 8.60E-02 | 1.58 | Upregulated | |
60S ribosomal protein L6 (RPL6) | 6.38E-03 | 8.60E-02 | 2.14 | Upregulated |