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Fig. 5 | BMC Cancer

Fig. 5

From: Proteomic characterization of paired non-malignant and malignant African-American prostate epithelial cell lines distinguishes them by structural proteins

Fig. 5

Tumor-to-non-malignant comparison of RNA expression of the differentially expressed proteins by race in age- and stage-matched human prostate cancer specimens. Race-specific non-malignant mRNA expression levels of PRAD specimens were subtracted from 12 pairs of age- and stage-matched prostate cancer specimens extracted from TCGA, respectively. CAV1 and CTNNB1 mRNA expressions were found to be significantly higher in African-American compared to Caucasian-American specimens (p < 0.05 and <0.01, respectively). The p-values were generated using the “t.test” function in R. As indicated by the negative RNA expression value on the y-axis, CAV1 was downregulated in African American prostate cancer specimens compared to African American non-malignant control specimens. On the contrary, CTNNB1 was upregulated. AA = African-American; ADAR = double-stranded RNA-specific adenosine deaminase; CA = Caucasian-American; CAV1 = caveolin-1; CTNNB1 = beta-catenin; MYH9 = myosin heavy chain-9; PRAD = prostate cancer adenocarcinoma; SRSF1 = serine/arginine-rich splicing factor 1; TCGA = The Cancer Genome Atlas; XRCC5 = X-ray repair cross-complementing protein 5

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