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Table 6 Sample size calculation (two-sided test with power = 0.80) to identify mean difference in H score between biopsy and radical prostatectomy specimen for the metformin and control group

From: Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localised prostate cancer

  Mean Difference (SD)
in Metformin Group
Mean Difference (SD)
in Control Group
N needed
with α = 0.05
N needed
with α = 0.10
N needed
with α = 0.20
Scenario 1 15 (35) 0 (35) 86 38 50
Scenario 2 30 (65) 0 (65) 74 59 43
Scenario 3 20 (25) 5 (25) 44 35 26
Scenario 4 30 (50) 5 (50) 63 50 37