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Table 4 Dose reduction for specific toxicity: diarrhoea

From: Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localised prostate cancer

Grade I No action required.
Grade II Concomitant anti-diarrhoeal agents may initially be administered without dose reduction. If Grade 2 diarrhoea persists, dose reduction should occur as per Table 2. Supportive care regimen should follow local standard of care.
Grade III Dose reduction should occur as per Table 2.
Grade IV Dose reduction should occur as per Table 2.