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Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localised prostate cancer

  • Danielle Crawley1Email author,
  • Ashish Chandra2,
  • Massimo Loda3,
  • Cheryl Gillett4,
  • Paul Cathcart2,
  • Ben Challacombe2,
  • Gary Cook5,
  • Declan Cahill6,
  • Aida Santa Olalla1,
  • Fidelma Cahill1,
  • Gincy George1,
  • Sarah Rudman2 and
  • Mieke Van Hemelrijck1
BMC Cancer201717:494

Received: 26 January 2017

Accepted: 26 June 2017

Published: 21 July 2017

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
26 Jan 2017 Submitted Original manuscript
6 Mar 2017 Author responded Author comments - Danielle Crawley
Resubmission - Version 2
6 Mar 2017 Submitted Manuscript version 2
26 Jun 2017 Editorially accepted
21 Jul 2017 Article published 10.1186/s12885-017-3458-3

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Division of Cancer Studies, Cancer Epidemiology Group, Research Oncology, King’s College London
Guy’s and St Thomas’ NHS Foundation Trust
Department of Medical Oncology, Dana-Farber Cancer Institute
Division of Cancer Studies, King’s College London
Division of Imaging Sciences and Biomedical Engineering, King’s College London
Royal Marsden NHS Foundation Trust