Fig. 2
MRI images and functional parameter maps produced as per study protocol. Images for a patient with good response to chemoradiotherapy (CRT) with histopathology tumour regression grade 1 (AJCC 7th Edition). The rectal tumour is indicated by the arrow. In the T2-weighted week 3 image, it was difficult to distinguish residual tumour deposits within areas of radiation-induced necrosis. Early tumour response to therapy can be seen in the functional sequences. In the DWI-RESOLVE images, there was a reduction in tumour signal enhancement in week 3. The calculated b = 1400 mm/s2 images demonstrated increased signal intensity in tumour relative to surrounding normal tissues. Ktrans maps were produced in Siemens Tissue 4D and a reduction in Ktrans was seen in week 3