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Table 2 Regimens and doses of chemotherapy

From: The effect of geriatric intervention in frail elderly patients receiving chemotherapy for colorectal cancer: a randomized trial (GERICO)

Adjuvant setting
Regimen Drug Dose Frequency
Capecitabine Capecitabine 2000 mg/m2 p.o. daily for 14 days Every 3 weeks*
5-FU 5-FU
Calcium folinate
400 mg/m2 i.v.
Infusion 46 h: 2400 mg/ m2 i.v.
400 mg/m2 i.v.
Every 2 weeks**
Capeox Capecitabine
Oxaliplatin
2000 mg/m2 p.o. daily for 14 days
130 mg/m2 i.v.
Every 3 weeks*
Folfox 5-FU
Calcium folinate
Oxaliplatin
400 mg/m2 i.v.
Infusion 46 h: 2400 mg/ m2 i.v.
400 mg/m2 i.v.
85 mg/m2 i.v.
Every 2 weeks**
Metastatic setting
Regimens Drug Dose Frequency
Capecitabine Capecitabine 2000 mg/m2 p.o. daily for 14 days Every 3 weeks*
5-FU 5-FU
Calcium folinate
400 mg/m2 i.v.
Infusion 46 h: 2400 mg/ m2 i.v.
400 mg/m2 i.v.
Every 2 weeks**
Capeox Capecitabine
Oxaliplatin
2000 mg/m2 p.o. daily for 14 days
130 mg/m2 i.v.
Every 3 weeks*
Folfox 5-FU
Calcium folinate
Oxaliplatin
400 mg/m2 i.v.
Infusion 46 h: 2400 mg/ m2 i.v.
400 mg/m2 i.v.
85 mg/m2 i.v.
Every 2 weeks***
Irinotecan Irinotecan 200 mg/m2 i.v. Every 2 weeks****
Capiri Capecitabine
Irinotecan
1600 mg/m2 p.o. daily for 14 days
200 mg/m2 i.v.
Every 3 weeks *
Folfiri 5-FU
Calcium folinate
Irinotecan
400 mg/m2 i.v.
Infusion 46 h: 2400 mg/ m2 i.v.
400 mg/m2 i.v.
180 mg/m2 i.v.
Every 2 weeks****
Irox Irinotecan
Oxaliplatin
165 mg/m2 i.v.
85 mg/m2 i.v.
Every 2 weeks****
  1. *maximum 8 series
  2. **maximum 12 series
  3. i.v. intravenous, p.o. per os
  4. *optional addition of bevacizumab 7.5 mg/m2 i.v
  5. **optional addition of bevacizumab 5 mg/m2 i.v
  6. ***optional addition of bevacizumab 5 mg/m2 i.v., irinotecan 165 mg/m2 i.v., cetuximab 500 mg/m2 i.v., or panitumumab 6 mg/kg i.v
  7. ****optional addition of bevacizumab 5 mg/m2 i.v., cetuximab 500 mg/m2 i.v., or panitumumab 6 mg/kg i.v