Fig. 4

Knockdown of MCL-1 expression inhibits tumor growth in vivo. a Photographs of tumors dissected from mice (n = 10) injected with KYSE150-shGFP or KYSE150-shMCL-1#2 cells. b Tumor growth curve from each group was shown. c Average body weight of mice from each group was shown. d Total average tumor weight from each group was shown. Data were represented as means ± SD of each group. *p < 0.05, **p < 0.01 and ***p < 0.001, significant difference compared with the group injected with KYSE150-shGFP cells. e Immunohistochemical examination of Ki67 and MCL-1 in tumor sections from KYSE150-shGFP or KYSE150-shMCL-1#2 xenograft mice. Representative photographs for each antibody and each group were shown (original magnification, ×200)