Fig. 5

PF-3758309 inhibited colorectal tumour growth and increased the numbers of circulating neutrophils and lymphocytes in APC^∆14/+ mice. 10-week old APC^+/+ (n = 6) and APC^∆14/+ (n = 18) mice were treated with PF-3758309 by peritoneal injection (25 mg/Kg) for 10 weeks. Control APC^+/+ (n = 6) and APC^∆14/+ (n = 16) mice were treated with 5% DMSO in saline. The mice were culled by 21 weeks of age, blood was taken for full blood cell count (c), small intestine and colon/rectum were dissected out and tumours counted (a), and the spleens were weighed (d). The tumour incidence (b) was calculated by dividing the number of mice that developed tumours by the total number of mice used for the experiment and multiplying by 100. *, p < 0.05 compared to control; ###, p < 0.001 compared to APC^+/+ mice