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Table 3 Clinicopathological features of hepatocellular carcinomas with positive YAP1 expression (N = 624)

From: The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

  N (%) p-value
Sex Male[518] vs. Female[106] 16(3) vs. 4 (4) 0.715
Age (yr) ≤55[324] vs. >55[300] 9(3) vs. 11 (4) 0.681
Size (cm) ≤5.0[379] vs. >5.0[235] 12(3) vs. 8 (3) 0.872
Multiplicity Single[449] vs. Multiple[169] 11(2) vs. 9 (5) 0.072
Vascular invasion Absent[330] vs. Present[286] 10(3) vs. 10 (3) 0.745
Large vessel invasion Absent[578] vs. Present[37] 18(3) vs. 2 (5) 0.446
pT stage (AJCC 7th) pT1–2[486] vs. pT3–4[138] 16(3) vs. 4 (3) 0.982
ES nuclear grade 1–2[300] vs. 3–4[313] 4(1) vs. 15 (5) 0.014*
Preoperative treatment Done[261] vs. Not done[315] 13(5) vs. 6 (2) 0.114
Serum AFP (ng/ml) ≤32[309] vs. >32[289] 4(1) vs. 14 (5) 0.011*
Cell type Hepatic[539] vs. Non-hepatic[61] 17(3) vs. 2 (3) 0.958
Histologic pattern Trabecular/acinar[487] vs. Compact[113] 12(2) vs. 7 (6) 0.041*
Desmoplastic stroma Absent[462] vs. Present[113] 9(2) vs. 9 (8) <0.001*
Expression of CK19 Negative[523] vs. Positive[101] 10(2) vs. 10 (10) <0.001*
Etiology of CLD Viral[557] vs. Non-viral[36] 19(3) vs. 0 (0) 0.621
  1. *p-value <0.05; ES nuclear grade, Edmonson-Steiner nuclear grade; CLD chronic liver disease