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Table 1 Patient demographics (N = 913)

From: The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

  HCC (624) cHC-CCA (31) IHCCA (239) EHBCA (19) p-value
Stem cell (16) Classical (15) CLC(24) Non-CLC(215)
Sex (M:F ratio) 4.9 2.2 14 2 2.9 1.1 0.001*
 Male 518(83) 11(69) 14(93) 16(67) 160(74) 10(53) 0.001*
 Female 106(17) 5(31) 1(7) 8(33) 55(26) 9(47)  
Age (year, mean ± SD) 54 ± 10 51 ± 12 58 ± 8 60 ± 10 62 ± 9 58 ± 12 <0.001*
Chronic liver disease 593(95) 16(100) 12(80) 12(50) 39(18) 0(0) <0.001*
 Viral 557(94) 10(63) 9(75) 7(58) 27(69) 0(0) <0.001*
 Non-viral 36(6) 5(31) 3(25) 5(42) 12(31) 0(0)  
pT stage (AJCC 7th)
 pT1 256(41) 9(56) 3(20) 7(29) 81(38) 1(5) 0.01*
 pT2-pT4 360(58) 7(44) 12(80) 17(71) 131(61) 17(89)  
Progress
 Recur or metastasis 395(63) 7(44) 10(67) 11(46) 144(67) 12(63) <0.001*
 PFS (median, month) 26 103 12 NA 11 20 <0.001*
Death
 Deceased 352(56) 6(38) 10(67) 6(25) 110(51) 18(95) <0.001*
 OS (median, month) 77 91 21 NA 61 18 <0.001*
  1. HCC hepatocellular carcinoma, CCA cholangiocarcinoma, IHCCA intrahepatic cholangiocarcinoma, EHBCA extrahepatic bile duct carcinoma, CLC cholangiolocellular, PFS progression- free survival, OS overall survival, NA not applicable; *p-value <0.05