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Table 5 Number needed to test to identify one mutation carrier according to test criteria

From: Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers

Test criteria Mutation frequency Number needed to test (NNT) to identify one mutation carrier
BC < 50 years 10/116 = 8.6% 12
BC < 60 years 13/235 = 5.5% 18
TNBC 5/35 = 14% 7
NBCG criteria 12/147 = 8.2% 12