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Fig. 4 | BMC Cancer

Fig. 4

From: Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

Fig. 4

Working model of the roles of MMP-2 and MMP-9 in retinoblastoma cells. Y79 and Weri-1 cells represent the metastatic and the non-metastatic model for Rb, respectively. Our work shows differences in viability, migration and angiogenic-associated responses in Rb cells after inhibition of MMP-2 and MMP-9. a Y79 cells showed a profound defect in migration and invasion along with and a significant reduction in Angiopoietin-2 and TGF-β1 proteins. These results highlight Y79’s migratory and invasive potential, which may be dependent upon MMPs. b Analyses of Weri-1 cells show MMP-2 and MMP-9 are involved in multiple processes, including viability of cells and VEGF, as well as TGF-β1 production

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