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Fig. 4 | BMC Cancer

Fig. 4

From: Dickkopf-4 is frequently overexpressed in epithelial ovarian carcinoma and promotes tumor invasion

Fig. 4

The analysis of DKK4 knowdown on cell invasion through inhibiting JNK activation. a Western blot analysis of c-JUN and JNK protein expression in 10 EOC cancer tissues and 10 benign ovarian tumors. b-e Western blot analysis of p-c-JUN and p-JNK level in DKK4 siRNA SKOV-3 and HO-8910 cells and control cells. f-g Transwell assay showed that JNK silence, mediated by JNK inhibitor SP600125, inhibited the invasive ability of SKOV-3 and HO-8910 cells; *, p < 0.05; N = 3

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