| |
Severe diarrhea
|
Severe neutropenia
|
Severe toxicity
|
|---|
|
Genotype
|
N/Total(%)
|
P value
|
N/Total(%)
|
P value
|
No.(%)
|
P value
|
|---|
|
UGT1A1*6/*28 panels (N = 661)
|
|
Wild typea
|
31/368(8.4%)
| |
59/368(16.0%)
| |
84/368(22.8%)
| |
|
Single allele variantsb
|
23/228(10.1%)
| |
53/228(23.2%)
| |
66/228(28.9%)
| |
| ≧2 alleles variantsc
|
5/65(7.7%)
|
0.736
|
24/65(36.9%)
|
<0.001
|
29/65(44.6%)
|
0.001
|
|
UGT1A1*6/*28 and DPYD*5 panels (N = 496)
|
|
Wild typed
|
5/114(4.4%)
| |
17/114(14.9%)
| |
20/114(17.5%)
| |
|
Single allele variantse
|
22/214(10.3%)
| |
36/214(16.8%)
| |
54/214(25.2%)
| |
|
2 alleles variantsf
|
12/124(9.7%)
| |
37/124(29.8%)
| |
44/124(35.5%)
| |
| ≧3 alleles variantsg
|
7/44(15.9%)
|
0.147
|
14/44(31.8%)
|
0.008
|
21/44(47.7%)
|
0.001
|
-
apatients with genotype: G/G and TA6/TA6. bpatients with genotype: G/A, and TA6/TA6; or G/G and TA6/TA7. cpatients with genotype: A/A and TA6/TA6; or G/A and TA6/TA7; or G/G and TA7/TA7; or A/A and TA6/TA7. dpatients with genotype: G/G, TA6/TA7 and A/A. epatients with genotype: G/A, TA6/TA6 and A/A; or G/G, TA6/TA7 and A/A; or G/G, TA6/TA6, A/G. fpatients with genotype: G/A, TA6/TA7 and A/A; or G/G, TA6/TA6 and G/G; or G/G, TA7/TA7 and A/A; A/A, TA6/TA6 and A/A. gpatients with genotype: G/A, TA6/TA7 and A/G; or A/A, TA6/TA6 and A/G; or G/G, TA7/TA7 and G/G; or G/A, TA6/TA7 and G/G; or A/A, TA6/TA6 and G/G
