Table 3 Univariate and multivariate analysis of chemotherapy induced toxicity
Severe diarrhea | Severe neutropenia | |||||||
|---|---|---|---|---|---|---|---|---|
Factors | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
N/Total(%) | P value | OR(95%CI) | P value | N/Total(%) | P value | OR(95%CI) | P value | |
Sex | ||||||||
 Male | 39/406(9.6%) | 73/406(18.0%) | ||||||
 Female | 20/255(7.8%) | 0.439 | NAa | NA | 63/255(24.7%) | 0.037 | 1.538(0.989–2.393) | 0.056 |
Age | ||||||||
 ≦65y | 44/545(8.1%) | 119/545(21.8%) | ||||||
 >65y | 15/116(12.9%) | 0.096 | NA | NA | 17/116(14.7%) | 0.082 | NA | NA |
Primary tumor locationb | ||||||||
 Left-side colorectum | 48/487(9.9%) | 97/487(19.9%) | ||||||
 Right-side colon | 11/174(6.3%) | 0.160 | NA | NA | 39/174(22.4%) | 0.485 | NA | NA |
Chemotherapy regimens | ||||||||
 Single IRI based regimens | 8/71(11.3%) | 9/71(12.7%) | ||||||
 IRIc + fluorouracil based regimens | 51/590(8.6%) | 0.464 | NA | NA | 127/590(21.5%) | 0.081 | NA | NA |
Line of treatment | ||||||||
 First line treatment | 9/98(9.2%) | 30/98(30.6%) | ||||||
 ≧Second line treatment | 50/563(8.9%) | 0.923 | NA | NA | 106/563(18.8%) | 0.008 | 0.504(0.301–0.845) | 0.009 |
UGT1A1*6 | ||||||||
 G/G | 42/431(9.7%) | 79/431(18.3%) | ||||||
 G/A | 14/198(7.1%) | 43/198(21.7%) | 1.376(0.854–2.215) | 0.189 | ||||
 A/A | 3/32(9.4%) | 0.548 | NA | NA | 14/32(43.8%) | 0.002 | 4.737(1.946–11.533) | 0.001 |
UGT1A1*27 | ||||||||
 C/A | 0/10(0.0%) | 109/535(20.4%) | ||||||
 C/C | 53/535(9.9%) | 0.609 | NA | NA | 2/10(20.0%) | 0.977 | NA | NA |
UGT1A1*28 | ||||||||
 TA6/TA6 | 40/501(8.0%) | 90/501(18.0%) | ||||||
 TA6/TA7 | 18/152(11.8%) | 42/152(27.6%) | 2.263(1.395–3.670) | 0.001 | ||||
 TA7/TA7 | 1/8(12.5%) | 0.323 | NA | NA | 4/8(50.0%) | 0.004 | 5.910(1.138–30.682) | 0.034 |
UGT1A7 | ||||||||
  UGT1A7*1/*1,*1/*2,*2/*2 | 31/330(9.4%) | 54/330(16.4%) | ||||||
  UGT1A7*1/*3,*2/*3,*3/*3 | 22/215(10.2%) | 0.747 | NA | NA | 57/215(26.5%) | 0.004 | NA | NA |
UGT1A9*22 | ||||||||
 T9/T9 | 10/99(10.1%) | 26/99(26.3%) | ||||||
 T9/T10,T10/T10 | 43/446(9.6%) | 0.889 | NA | NA | 85/446(19.1%) | 0.107 | NA | NA |
DPYD*5 | ||||||||
 A/A | 16/256(6.3%) | 53/256(20.7%) | ||||||
 A/G | 30/240(12.5%) | 0.016 | 2.143(1.136–4.041) | 0.019 | 51/240(21.3%) | 0.881 | NA | NA |
DPYD c.1896 T > C | ||||||||
 T/T | 32/395(8.1%) | 84/395(21.3%) | ||||||
 T/T,T/C | 14/101(13.9%) | 0.075 | NA | NA | 20/101(19.8%) | 0.747 | NA | NA |