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Table 3 Univariate and multivariate analysis of chemotherapy induced toxicity

From: Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis

  Severe diarrhea Severe neutropenia
Factors Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
  N/Total(%) P value OR(95%CI) P value N/Total(%) P value OR(95%CI) P value
Sex
 Male 39/406(9.6%)     73/406(18.0%)    
 Female 20/255(7.8%) 0.439 NAa NA 63/255(24.7%) 0.037 1.538(0.989–2.393) 0.056
Age
65y 44/545(8.1%)     119/545(21.8%)    
 >65y 15/116(12.9%) 0.096 NA NA 17/116(14.7%) 0.082 NA NA
Primary tumor locationb
 Left-side colorectum 48/487(9.9%)     97/487(19.9%)    
 Right-side colon 11/174(6.3%) 0.160 NA NA 39/174(22.4%) 0.485 NA NA
Chemotherapy regimens
 Single IRI based regimens 8/71(11.3%)     9/71(12.7%)    
 IRIc + fluorouracil based regimens 51/590(8.6%) 0.464 NA NA 127/590(21.5%) 0.081 NA NA
Line of treatment
 First line treatment 9/98(9.2%)     30/98(30.6%)    
Second line treatment 50/563(8.9%) 0.923 NA NA 106/563(18.8%) 0.008 0.504(0.301–0.845) 0.009
UGT1A1*6
 G/G 42/431(9.7%)     79/431(18.3%)    
 G/A 14/198(7.1%)     43/198(21.7%)   1.376(0.854–2.215) 0.189
 A/A 3/32(9.4%) 0.548 NA NA 14/32(43.8%) 0.002 4.737(1.946–11.533) 0.001
UGT1A1*27
 C/A 0/10(0.0%)     109/535(20.4%)    
 C/C 53/535(9.9%) 0.609 NA NA 2/10(20.0%) 0.977 NA NA
UGT1A1*28
 TA6/TA6 40/501(8.0%)     90/501(18.0%)    
 TA6/TA7 18/152(11.8%)     42/152(27.6%)   2.263(1.395–3.670) 0.001
 TA7/TA7 1/8(12.5%) 0.323 NA NA 4/8(50.0%) 0.004 5.910(1.138–30.682) 0.034
UGT1A7
UGT1A7*1/*1,*1/*2,*2/*2 31/330(9.4%)     54/330(16.4%)    
UGT1A7*1/*3,*2/*3,*3/*3 22/215(10.2%) 0.747 NA NA 57/215(26.5%) 0.004 NA NA
UGT1A9*22
 T9/T9 10/99(10.1%)     26/99(26.3%)    
 T9/T10,T10/T10 43/446(9.6%) 0.889 NA NA 85/446(19.1%) 0.107 NA NA
DPYD*5
 A/A 16/256(6.3%)     53/256(20.7%)    
 A/G 30/240(12.5%) 0.016 2.143(1.136–4.041) 0.019 51/240(21.3%) 0.881 NA NA
DPYD c.1896 T > C
 T/T 32/395(8.1%)     84/395(21.3%)    
 T/T,T/C 14/101(13.9%) 0.075 NA NA 20/101(19.8%) 0.747 NA NA
  1. a: Non-acquired; b: Left-side colorectum included splenic flexure, descending colon, sigmoid colon and rectum; Right-side colon included cecum, ascending and transverse colon [18]; c: Irinotecan