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Table 5 Univariate and multivariate Cox regression analyses for cause-specific survival and overall survival (n = 72)

From: Clinical outcomes of transoral videolaryngoscopic surgery for hypopharyngeal and supraglottic cancer

Variables   Cause-specific survival Overall survival
No. Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
  HR (95% CI) P-values HR (95% CI) P-values HR (95% CI) P-values HR (95% CI) P-values
Age, y
  <70 45 1.00 reference   1.00 reference   1.00 reference   1.00 reference  
70 27 0.93 (0.22-3.89) 0.920 1.15 (0.24-5.42) 0.858 0.94 (0.34-2.60) 0.913 1.00 (0.34-2.89) 0.994
Sex
  Men 67 1.00    1.00    1.00 reference   1.00 reference  
Women 5 not calculablea not calculablea 0.61 (0.08-4.75) 0.636 1.27 (0.13-12.38) 0.835
Tumor site
  HPC 58 1.00 reference   1.00 reference   1.00 reference   1.00 reference  
SGC 14 0.57 (0.07-4.68) 0.605 0.38 (0.04-3.43) 0.386 0.60 (0.14-2.64) 0.498 0.54 (0.11-2.69) 0.450
T stage
  Tis + T1 32 1.00 reference   1.00 reference   1.00 reference   1.00 reference  
T2-3 40 2.69 (0.54-13.34) 0.227 0.68 (0.09-5.24) 0.714 1.58 (0.57-4.35) 0.380 1.27 (0.29-5.54) 0.749
N stage
  N0-1 48 1.00 reference   1.00 reference   1.00 reference   1.00 reference  
N2-3 24 15.45 (1.90-125.69) 0.010* 25.51 (2.29-284.17) 0.008* 2.94 (1.09-7.90) 0.032* 4.90 (1.26-19.08) 0.022*
Multiple cancer
  No 18 1.00 reference   1.00 reference   1.00 reference   1.00 reference  
Yes 54 1.08 (0.22-5.36) 0.923 2.63 (0.45-15.20) 0.281 1.21 (0.39-3.82) 0.742 1.74 (0.47-6.41) 0.405
Previous RT
  No 60 1.00 reference   1.00    1.00 reference   1.00 reference  
Yes 12 0.68 (0.08-5.52) 0.717 not calculableb 1.09 (0.31-3.83) 0.894 2.23 (0.34-14.86) 0.406
  1. HPC hypopharyngeal cancer, SGC supraglottic cancer, RT Radiotherapy, HR hazard ratio, CI confidence interval
  2. * Statistically significant (p < 0.05)
  3. aHR was not calculable because no woman died of the disease
  4. bHR was not calculable because of strong confounding with N stage